Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

被引：24
作者：
Bachu, Prabhakar [1 ]
Sperry, Jonathan [1 ]
Brimble, Margaret A. [1 ]
机构：
[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand
来源：
TETRAHEDRON | 2008年 / 64卷 / 21期
关键词：
eleutherin; thysanone; topoisomerase II inhibitor; 3C-protease inhibitor; Novozyme 4350 (Candida antarctica lipase); microwave assisted lipase kinetic resolution; intramolecular cyclization;
D O I：
10.1016/j.tet.2008.01.112
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 (R) as the key step. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4827 / 4834
页数：8
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