Yes, We Are Still Talking about Cylosporin vs. Infliximab in Steroid Resistant Acute Severe Ulcerative Colitis

被引：7

作者：

Bernstein, Charles N. ^{[1
,2
]}

Kornbluth, Asher ^{[3
]}

机构：

[1] Univ Manitoba, Max Rady Coll Med, IBD Clin & Res Ctr, 804F-715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada

[2] Univ Manitoba, Max Rady Coll Med, Dept Internal Med, 804F-715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada

[3] Icahn Sch Med Mt Sinai, Henry Janowitz Div Gastroenterol, New York, NY 10029 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2017年 / 112卷 / 11期

关键词：

RESCUE THERAPY; CYCLOSPORINE;

D O I：

10.1038/ajg.2017.282

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The Spanish IBD Registry (ENEIDA) is reporting in this issue of the Journal on a retrospective assessment of outcomes of cyclosporine use and infliximab use to treat steroid refractory acute severe ulcerative colitis (SR-ASUC) between 1989 and 2013. Overall, they found similar outcomes in terms of 3 month and 1 year colectomy rates. Serious adverse events were lower in cyclosporine users. While this study does not meet the standard of a prospective randomized controlled trial, it does remind us that cyclosporine can be effective in (SR-ASUC) and should be considered in those who have already failed antibody to tumor necrosis factor therapy or as a bridge to immunomodulators that have a slower onset of action.

引用

页码：1719 / 1721

页数：3

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