Concanavalin A: A potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics

被引：90
作者：
Li, Wen-wen
Yu, Jia-ying
Xu, Huai-long
Bao, Jin-ku [1 ]
机构：
[1] Sichuan Univ, Sch Life Sci, Chengdu 610064, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 414卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Concanavalin A (ConA); Anti-neoplastic; Apoptosis; Autophagy; Anti-angiogenesis; CELLS; INDUCTION; LECTINS; BINDING;
D O I：
10.1016/j.bbrc.2011.09.072
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Concanavalin A (ConA), a Ca2+/Mn2+-dependent and mannose/glucose-binding legume lectin, has drawn a rising attention for its remarkable anti-proliferative and anti-tumor activities to a variety of cancer cells. ConA induces programmed cell death via mitochondria-mediated, P73-Foxo1a-Bim apoptosis and BNIP3-mediated mitochondrial autophagy. Through IKK-NF-kappa B-COX-2, SHP-2-MEK-1-ERK, and SHP-2-Ras-ERK anti-angiogenic pathways, ConA would inhibit cancer cell survival. In addition, ConA stimulates cell immunity and generates an immune memory, resisting to the same genotypic tumor. These biological findings shed light on new perspectives of ConA as a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis in pre-clinical or clinical trials for cancer therapeutics. (C) 2011 Elsevier Inc. All rights reserved.
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页码：282 / 286
页数：5
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