The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle

被引：68
作者：
McKinney, Caleb C. [1 ]
Hussmann, Katherine L. [1 ]
McBride, Alison A. [1 ]
机构：
[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
VIRUSES-BASEL | 2015年 / 7卷 / 05期
基金：
美国国家卫生研究院;
关键词：
BROMODOMAIN PROTEIN BRD4; BOVINE PAPILLOMAVIRUS; E2; PROTEIN; VIRAL-DNA; PRODUCTIVE REPLICATION; EPISOMAL MAINTENANCE; GENOMIC INSTABILITY; E7; ONCOPROTEIN; FRAGILE SITES; E1;
D O I：
10.3390/v7052450
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection.
引用
收藏
页码：2450 / 2469
页数：20
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