Substituted, Fused, Tricyclic 6,7-Dihydro-1H,5H-pyrido[1,2,3-de]quinoxaline-3-amines by Isocyanide-Abetted Cycloaddition Reaction

被引：6

作者：

Azad, Chandra S. ^{[1
]}

Narula, Anudeep K. ^{[1
]}

机构：

[1] Guru Gobind Singh Indraprastha Univ, Hygeia, Ctr Excellence Pharmaceut Sci, Sect 16-C, New Delhi 110078, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 43期

关键词：

Cycloaddition; Fused-ring systems; Polycycles; Isocyanides; Multicomponent reactions; MULTICOMPONENT REACTIONS; 3,4-DIHYDROQUINOXALIN-2-AMINE DERIVATIVES; 1,6-DIHYDROPYRAZINE-2,3-DICARBONITRILE DERIVATIVES; 3-COMPONENT SYNTHESIS; AZOMETHINE IMINES; ORGANIC-SYNTHESIS; HETEROCYCLES; EFFICIENT; CATALYST; DIVERSITY;

D O I：

10.1002/ejoc.201701118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of substituted, fused, tricyclic 6,7-dihydro-1H,5H-pyrido[1,2,3-de]quinoxaline-3-amine derivatives from aldehydes, isocyanides, and 1,2,3,4-tetrahydroquinolin-8-amine in the presence of scandium(III) trifluoromethanesulfonate as the catalyst was developed. An inventive approach for the activation of the nitrilium ion with an in situ formed 4-(dimethylamino)pyridine-stabilized imine synthon was also explored to enhance the yield of the desired, fused, tricyclic systems.

引用

收藏

页码：6413 / 6416

页数：4

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