pH-responsive mesoporous silica drug delivery system for targeted cancer chemotherapy

被引：21
作者：
Bao, Wen [1 ,2 ]
Ma, Haibo [1 ,2 ]
Wang, Nan [1 ,2 ]
He, Zhanhang [1 ,2 ]
机构：
[1] Zhengzhou Univ, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
MATERIALS TECHNOLOGY | 2021年 / 36卷 / 05期
关键词：
Mesoporous silica; pH responsive; drug delivery; targeted therapy; CARBON DOTS; HYALURONIC-ACID; QUANTUM DOTS; NANOPARTICLES; CARRIERS; RELEASE; FUNCTIONALIZATION; DESIGN;
D O I：
10.1080/10667857.2020.1758474
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this paper, a kind of pH-responsive mesoporous silica targeted drug delivery system (DOX-loaded N-CQDs/HA gated pSiO(2)/MPEG-Glu) was designed and synthesised. In this system, active mesoporous silica (pSiO(2)) worked as a carrier material, methoxy polyethene glycol amine (MPEG) and L-glutamic acid (Glu) can be coupled and grafted to the surface of the pSiO(2) drug carrier to improve the stability of the drug delivery system, nitrogen-doped carbon quantum dots (N-CQDs) and hyaluronic acid (HA) can inhibit the rapid release of drug. Ultraviolet (UV-Vis) spectrum showed that the drug-loading rate of DOX is 8.9%, the drug release in vitro study suggested that the prepared silica drug delivery system had significant pH-responsive and targeted DOX release, the drug release rate is 55.7% at pH = 5.0, which was much higher than the release of pH = 7.4; CLSM and MTT showed that the drug delivery system can enter into cancer cells through endocytosis and the DOX can act on cell nucleus, exhibiting a targeted therapy on cancer cells.
引用
收藏
页码：308 / 316
页数：9
相关论文
共 42 条
[1]  
[Anonymous], J BIOMATER SCI POLYM
[2]  
[Anonymous], 2016, MAT TECHNOL
[3]   Green synthesized multiple fluorescent nitrogen-doped carbon quantum dots as an efficient label-free optical nanoprobe for in vivo live-cell imaging [J].
Atchudan, Raji ;
Edison, Thomas Nesakumar Jebakumar Immanuel ;
Perumal, Suguna ;
Selvam, N. Clament Sagaya ;
Lee, Yong Rok .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2019, 372 :99-107
[4]   pH-sensitive carbon quantum dots-doxorubicin nanoparticles for tumor cellular targeted drug delivery [J].
Bao, Wen ;
Ma, Haibo ;
Wang, Nan ;
He, Zhanhang .
POLYMERS FOR ADVANCED TECHNOLOGIES, 2019, 30 (11) :2664-2673
[5]   Fabrication of SnO2/porous silica/polyethyleneimine nanoparticles for pH-responsive drug delivery [J].
Cao, Na ;
Li, Miao ;
Zhao, Yanbao ;
Qiu, Li ;
Zou, Xueyan ;
Zhang, Yu ;
Sun, Lei .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 59 :319-323
[6]   Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: Sensitive response to the narrow pH range [J].
Chen, Fang ;
Zhu, Yingchun .
MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 150 (01) :83-89
[7]   Temperature responsive solution partition of organic-inorganic hybrid poly(N-isopropylacrylamide)-coated mesoporous silica nanospheres [J].
Chung, Po-Wen ;
Kumar, Rajeev ;
Pruski, Marek ;
Lin, Victor S. -Y. .
ADVANCED FUNCTIONAL MATERIALS, 2008, 18 (09) :1390-1398
[8]   Recent developments of molecular chemistry for sol-gel processes [J].
Corriu, RJP ;
Leclercq, D .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (13-14) :1420-1436
[9]   pH-responsive ultrasonic self-assembly spinosad-loaded nanomicelles and their antifungal activity to Fusarium oxysporum [J].
Dong, Enming ;
Yang, Ziming ;
Zhou, Chuang ;
Wang, Chao ;
Li, Sidong ;
Ouyang, Qianqian ;
Kong, Lingxue ;
He, Zuyu ;
Xie, Jianghui ;
Li, Puwang ;
Yang, Peihui .
REACTIVE & FUNCTIONAL POLYMERS, 2019, 141 :123-132
[10]   Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery [J].
Du, Xin ;
Shi, Bingyang ;
Tang, Youhong ;
Dai, Sheng ;
Qiao, Shi Zhang .
BIOMATERIALS, 2014, 35 (21) :5580-5590
12345