Analysis of Parkinson's Disease and Subsequent Cancer Risk in Taiwan: A Nationwide Population-Based Cohort Study

被引:27
作者
Sun, Li-Min [2 ]
Liang, Ji-An [3 ,6 ]
Chang, Shih-Ni [7 ,8 ,9 ]
Sung, Fung-Chang [4 ,8 ]
Muo, Chih-Hsin [4 ,8 ]
Kao, Chia-Hung [1 ,5 ,6 ]
机构
[1] China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan
[2] Zuoying Armed Forces Gen Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan
[3] China Med Univ Hosp, Dept Radiat Oncol, Taichung 404, Taiwan
[4] China Med Univ Hosp, Management Off Hlth Data, Taichung 404, Taiwan
[5] China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan
[6] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan
[7] China Med Univ, PhD Program Canc Biol & Drug Discovery, Taichung, Taiwan
[8] China Med Univ, Coll Publ Hlth, Inst Environm Hlth, Taichung, Taiwan
[9] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
关键词
Parkinson's disease; Cancer; Cohort study; CIGARETTE-SMOKING; COLORECTAL-CANCER; PREVALENCE; EPIDEMIOLOGY; METAANALYSIS;
D O I
10.1159/000331489
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Patients with Parkinson's disease (PD) are suggested to be at a lower risk for the development of certain cancers and at a higher risk for melanoma. The aim of this study is to evaluate the possible association between PD and malignancy in Taiwan. Materials and Methods: We used the data of the National Health Insurance System of Taiwan to assess this issue. The PD cohort contained 4,957 patients, and each patient was randomly frequency matched by age and sex with 4 people from the general population without PD. Cox's proportional hazard regression analysis was conducted to estimate the effects of PD on the cancer risk. Results: In patients with PD, the risk of developing overall cancer was marginally significantly lower than in subjects without PD [adjusted hazard ratio (HR) = 0.88; 95% CI = 0.78-0.99]. For individual cancers, the risks of developing colorectal and lung cancers among patients with PD were marginally significantly lower than in subjects without PD. In contrast, despite the higher HR for the development of melanoma, it did not reach statistical significance because of the relatively small sample size. Conclusion: Our study found that Taiwanese patients with PD have a lower risk of developing colorectal and lung cancers. The findings of this study are compatible with those of prior studies from other countries. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:114 / 119
页数:6
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