Caenorhabditis elegans: a model to understand host-microbe interactions

被引：74

作者：

Kumar, Arun ^{[1
]}

Baruah, Aiswarya ^{[2
]}

Tomioka, Masahiro ^{[3
]}

Iino, Yuichi ^{[3
,4
]}

Kalita, Mohan C. ^{[5
]}

Khan, Mojibur ^{[1
]}

机构：

[1] IASST, Div Life Sci, Mol Biol & Microbial Biotechnol Lab, Gauhati 781035, Assam, India

[2] Assam Agr Univ, Dept Agr Biotechnol, Jorhat 785013, Assam, India

[3] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan

[4] JST, CREST, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

[5] Gauhati Univ, Dept Biotechnol, Gauhati 781014, Assam, India

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 07期

关键词：

Commensal; Probiotics; Longevity; Dysbiosis; Pathogen; C; ELEGANS; OXIDATIVE STRESS; INNATE IMMUNITY; GUT MICROBIOTA; LIFE-SPAN; TRANSCRIPTION FACTOR; SERRATIA-MARCESCENS; SIGNALING PATHWAY; GENE-EXPRESSION; TASTE-AVERSION;

D O I：

10.1007/s00018-019-03319-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Host-microbe interactions within the gut are fundamental to all higher organisms. Caenorhabditis elegans has been in use as a surrogate model to understand the conserved mechanisms in host-microbe interactions. Morphological and functional similarities of C. elegans gut with the human have allowed the mechanistic investigation of gut microbes and their effects on metabolism, development, reproduction, behavior, pathogenesis, immune responses and lifespan. Recent reports suggest their suitability for functional investigations of human gut bacteria, such as gut microbiota of healthy and diseased individuals. Our knowledge on the gut microbial diversity of C. elegans in their natural environment and the effect of host genetics on their core gut microbiota is important. Caenorhabditis elegans, as a model, is continuously bridging the gap in our understanding the role of genetics, environment, and dietary factors on physiology of the host.

引用

页码：1229 / 1249

页数：21

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