Association of the asporin D14 allele with lumbar-disc degeneration in Asians

被引：98

作者：

Song, You-Qiang ^{[1
,3
]}

Cheung, Kenneth M. C. ^{[2
]}

Ho, Daniel W. H. ^{[1
]}

Poon, Sandy C. S. ^{[1
]}

Chiba, Kazuhiro ^{[4
]}

Kawaguchi, Yoshiharu ^{[4
,5
]}

Hirose, Yuichiro ^{[10
]}

Alini, Mauro ^{[6
]}

Grad, Sibylle ^{[6
]}

Yee, Anita F. Y. ^{[2
]}

Leong, John C. Y. ^{[7
]}

Luk, Keith D. K. ^{[2
]}

Yip, Shea-Ping ^{[8
]}

Karppinen, Jaro ^{[9
]}

Cheah, Kathryn S. E. ^{[1
]}

Sham, Pak ^{[3
]}

Ikegawa, Shiro ^{[10
]}

Chan, Danny ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Genome Res Ctr, Hong Kong, Hong Kong, Peoples R China

[4] Keio Univ, Dept Orthopaed Surg, Tokyo 1608582, Japan

[5] Toyama Univ, Dept Orthopaed Surg, Toyama 9300194, Japan

[6] AO Fdn, Davos, Switzerland

[7] Open Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China

[8] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Hong Kong, Peoples R China

[9] Finnish Inst Occupat Hlth, Oulu 90220, Finland

[10] RIKEN, SNP Res Ctr, Lab Bone & Joint Dis, Tokyo 1088639, Japan

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2008年 / 82卷 / 03期

关键词：

D O I：

10.1016/j.ajhg.2007.12.017

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.

引用

页码：744 / 747

页数：4

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