Synthesis, antitubercular and antimicrobial activities of some new pyrazoline and isoxazole derivatives

被引：0

作者：

Vyas, D. H. ^{[1
]}

Tala, S. D. ^{[1
]}

Dhaduk, M. F. ^{[1
]}

Akbari, J. D. ^{[1
]}

Joshi, H. S. ^{[1
]}

机构：

[1] Saurashtra Univ, Dept Chem, Rajkot 360005, Gujarat, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2007年 / 84卷 / 11期

关键词：

pyrazolines; isoxazoles; microbial activity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclocondensation of hydrazine hydrate with (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones (1a-j) in glacial acetic acid afford corresponding 1-acetyl-3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-4,5-dihydro-1H-pyrazoles (2a-j). While the compounds 1a-j on reaction with hydroxylamine hydrochloride in presence of acetic acid and sodium acetate to give 3-(3,5-dibromo-4-methoxyphenyl)-5-aryl-isoxazoles (3a-j). All the compounds were tested against different microbes for their antimicrobial activity and compounds 2a-j were tested for antitubercular activity.

引用

页码：1140 / 1144

页数：5

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