The Bottlenecks in Translating Placenta-Derived Amniotic Epithelial and Mesenchymal Stromal Cells Into the Clinic: Current Discrepancies in Marker Reports

被引：27
作者：
Ghamari, Seyyed-Hadi [1 ]
Abbasi-Kangevari, Mohsen [2 ]
Tayebi, Tahereh [1 ]
Bahrami, Soheyl [3 ]
Niknejad, Hassan [1 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Student Res Comm, Social Determinants Hlth Res Ctr, Tehran, Iran
[3] AUVA Res Ctr, Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷
关键词：
amniotic epithelial cells; cell heterogeneity; cross-contamination; epithelial to mesenchymal transition; isolation protocol; mesenchymal stromal cells; passage number; simultaneous isolation; IN-VITRO DIFFERENTIATION; HUMAN BONE-MARROW; STEM-CELLS; IMMUNOMODULATORY PROPERTIES; CONDITIONED MEDIUM; FETAL MEMBRANES; TRANSPLANTATION; EXPRESSION; IMMUNOGENICITY; PROLIFERATION;
D O I：
10.3389/fbioe.2020.00180
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Placenta-derived amniotic cells have prominent features for application in regenerative medicine. However, there are still discrepancies in the characterization of human amniotic epithelial and mesenchymal stromal cells. It seems crucial that the characterization of human amniotic membrane cells be investigated to determine whether there are currently discrepancies in their characterization reports. In addition, possible causes for the witnessed discrepancies need to be addressed toward paving the way for further clinical application and safer practices. The objective of this review is to investigate the marker characterization as well as the potential causes of the discrepancies in the previous reports on placenta-derived amniotic epithelial and mesenchymal stromal cells. The current discrepancies could be potentially due to reasons including passage number and epithelial to mesenchymal transition (EMT), cell heterogeneity, isolation protocols and cross-contamination, the region of cell isolation on placental disk, measuring methods, and gestational age.
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页数：13
相关论文
共 128 条
[1]   Potential Therapeutic Features of Human Amniotic Mesenchymal Stem Cells in Multiple Sclerosis: Immunomodulation, Inflammation Suppression, Angiogenesis Promotion, Oxidative Stress Inhibition, Neurogenesis Induction, MMPs Regulation, and Remyelination Stimulation [J].
Abbasi-Kangevari, Mohsen ;
Ghamari, Seyyed-Hadi ;
Safaeinejad, Fahimeh ;
Bahrami, Soheyl ;
Niknejad, Hassan .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[2]   Bacterial contamination of amniotic membrane [J].
Adds, PJ ;
Hunt, C ;
Hartley, S .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2001, 85 (02) :228-230
[3]  
Ahmed Abu Shufian Ishtiaq, 2017, World J Exp Med, V7, P1, DOI 10.5493/wjem.v7.i1.1
[4]   Autocrine TGF-β Induces Epithelial to Mesenchymal Transition in Human Amniotic Epithelial Cells [J].
Alcaraz, Antonia ;
Mrowiec, Anna ;
Insausti, Carmen L. ;
Garcia-Vizcaino, Eva M. ;
Ruiz-Canada, Catalina ;
Lopez-Martinez, Maria C. ;
Moraleda, Jose M. ;
Nicolas, Francisco J. .
CELL TRANSPLANTATION, 2013, 22 (08) :1351-1367
[5]  
Alikarami Fatemeh, 2015, Avicenna Journal of Medical Biotechnology, V7, P90
[6]   Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro [J].
Alviano, Francesco ;
Fossati, Valentina ;
Marchionni, Cosetta ;
Arpinati, Mario ;
Bonsi, Laura ;
Franchina, Michele ;
Lanzoni, Giacomo ;
Cantoni, Silvia ;
Cavallini, Claudia ;
Bianchi, Francesca ;
Tazzari, Pier Luigi ;
Pasquinelli, Gianandrea ;
Foroni, Laura ;
Ventura, Carlo ;
Grossi, Alberto ;
Bagnara, Gian Paolo .
BMC DEVELOPMENTAL BIOLOGY, 2007, 7
[7]   Isolation of human mesenchymal stem cells from amnion, chorion, placental decidua and umbilical cord: comparison of four enzymatic protocols [J].
Araujo, A. B. ;
Furlan, J. M. ;
Salton, G. D. ;
Schmalfuss, T. ;
Rohsig, L. M. ;
Silla, L. M. R. ;
Passos, E. P. ;
Paz, A. H. .
BIOTECHNOLOGY LETTERS, 2018, 40 (06) :989-998
[8]   Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord [J].
Araujo, Anelise Bergmann ;
Salton, Gabrielle Dias ;
Furlan, Juliana Monteiro ;
Schneider, Natalia ;
Angeli, Melissa Helena ;
Laureano, Alvaro Macedo ;
Silla, Lucia ;
Passos, Eduardo Pandolfi ;
Paz, Ana Helena .
CYTOTHERAPY, 2017, 19 (05) :577-585
[9]   Human amnion cells for the prevention of bronchopulmonary dysplasia: a protocol for a phase I dose escalation study [J].
Baker, Elizabeth Kate ;
Malhotra, Atul ;
Lim, Rebecca ;
Jacobs, Susan E. ;
Hooper, Stuart B. ;
Davis, Peter G. ;
Wallace, Euan M. .
BMJ OPEN, 2019, 9 (02)
[10]   Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells [J].
Banas, Richard Allan ;
Trumpower, Catherine ;
Bentlejewski, Carol ;
Marshall, Vivienne ;
Sing, George ;
Zeevi, Adriana .
HUMAN IMMUNOLOGY, 2008, 69 (06) :321-328
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