Efficacy of high-intensity aerobic exercise on common multiple sclerosis symptoms

被引:21
作者
Langeskov-Christensen, Martin [1 ]
Hvid, Lars Grondahl [1 ]
Jensen, Henrik Boye [2 ,3 ]
Nielsen, Helle Hvilsted [4 ,5 ,6 ]
Petersen, Thor [7 ]
Stenager, Egon [3 ]
Dalgas, Ulrik [1 ]
机构
[1] Aarhus Univ, Dept Publ Hlth, Exercise Biol, Aarhus, Denmark
[2] Lillebaelt Hosp, Brain & Nerve Dis, Kolding, Denmark
[3] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark
[4] Univ Southern Denmark, Inst Mol Med, Dept Neurobiol Res, Odense, Denmark
[5] Odense Univ Hosp, Dept Neurol, Odense, Denmark
[6] Univ Southern Denmark, Dept Clin Res, BRIDGE Brain Res Interdisciplinary Guided Excelle, Odense, Denmark
[7] Aarhus Univ Hosp, Dept Neurol, Multiple Sclerosis Clin, Aarhus, Denmark
来源
ACTA NEUROLOGICA SCANDINAVICA | 2022年 / 145卷 / 02期
关键词
aerobic training; exercise therapy; fatigue; rehabilitation; WALKING SPEED; FATIGUE; SEVERITY; PEOPLE; SCALE;
D O I
10.1111/ane.13540
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives Fatigue and walking impairment are disabling symptoms of multiple sclerosis (MS). We investigated the effects of progressive aerobic exercise (PAE) on fatigue, walking, cardiorespiratory fitness (VO(2)max), and quality of life in people with MS (pwMS). Materials & Methods Randomized controlled trial (1:1 ratio, stratified by sex) with a 24-week crossover follow-up and intention-to-treat analysis. Allocation to an exercise (24 weeks of PAE followed by self-guided physical activity) and a waitlist (24 weeks of habitual lifestyle followed by PAE) group. PAE comprised two supervised sessions per week; 30-60 min, 65-95% of maximum heart rate. Fatigue impact (Modified Fatigue Impact Scale; MFIS) and severity (Fatigue Severity Scale; FSS), walking ability (12-item MS Walking Scale; MSWS-12) and capacity (Six-Minute Walk Test; 6MWT, Six Spot Step Test; SSST), quality of life (Short Form 36 health survey; SF-36), and VO(2)max were measured at baseline, 24 weeks, and 48 weeks. Results Eighty-six pwMS were enrolled. Following PAE between-group differences showed reductions in MFIStotal (-5.3 [95% CI: -10.9;0.4], point estimate >clinical relevance), MFISphysical subscore (-2.8 [-5.6;-0.1]), and MFISpsychosocial subscore (-0.9 [-1.6;-0.2]), and an increase in VO(2)max (+3.5 ml O-2/min/kg [2.0;5.1]). MSWS-12 (-5.9 [-11.9; 0.2]) and 6MWT (+14 m [-5;33]) differences suggested potential small walking improvements. No changes observed in FSS, SSST, or SF-36. Conclusions In a representative sample of pwMS, PAE induced a clinically relevant reduction in fatigue impact, whereas small and no effects were seen for walking and quality of life, respectively. The results need confirmation in a future trial due to the study limitations.
引用
收藏
页码:229 / 238
页数:10
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