Long term results of Dorsal Root Entry Zone (DREZ) lesions for the treatment of intractable pain: A systematic review of the literature on 1242 cases

被引：13

作者：

Mongardi, Lorenzo ^{[1
]}

Visani, Jacopo ^{[1
]}

Mantovani, Giorgio ^{[1
]}

Vitali, Costanza ^{[2
]}

Ricciardi, Luca ^{[3
]}

Giordano, Flavio ^{[4
]}

Cavallo, Michele Alessandro ^{[1
,5
]}

Lofrese, Giorgio ^{[6
]}

D'andrea, Marcello ^{[6
]}

Roblot, Paul ^{[7
]}

De Bonis, Pasquale ^{[1
,5
]}

Scerrati, Alba ^{[1
,5
]}

机构：

[1] St Anna Univ Hosp, Dept Neurosurg, Ferrara, Italy

[2] Univ Ferrara, Sect Anaesthesia & Intens Care, Azienda Osped Univ St Anna, Dept Morphol Surg & Expt Med, Ferrara, Italy

[3] Pia Fdn Culto & Relig Cardinal G Panico, UO Neurochirurg, Tricase, LE, Italy

[4] Univ Florence, Childrens Hosp A Meyer, Dept Neurosurg, Florence, Italy

[5] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[6] Bufalini Hosp, Neurosurg, Cesena, Italy

[7] Univ Hosp Bordeaux, Dept Neurosurg, Bordeaux, France

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2021年 / 210卷

关键词：

Root entry zone; DREZ; DREZotomy; Chronic pain; Intractable pain; BRACHIAL-PLEXUS AVULSION; PHANTOM LIMB PAIN; MICROSURGICAL DREZOTOMY; DEAFFERENTATION PAIN; NEUROPATHIC PAIN; FOLLOW-UP; CENTRAL SENSITIZATION; CONUS MEDULLARIS; HORN; EXPERIENCE;

D O I：

10.1016/j.clineuro.2021.107004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Different Dorsal root entry zone (DREZ) lesion techniques have been reported as effective treatment for intractable painful conditions, though with contradictory results. Overall, good results were reported especially in specific conditions, such as pain due to brachial plexus avulsion, spinal cord injuries and oncological pain management. However, data on long term results in different clinical conditions are still missing. Objective: This study aims to systematically review the pertinent literature to evaluate indications, clinical outcomes, and complications of DREZ lesion (DREZotomy), in chronic pain management. Methods: A systematic literature review was conducted according to the PRISMA statement. Papers on DREZotomy for chronic pain in cancer, brachial plexus avulsion, spinal cord injury, post herpetic neuralgia, and phantom limb pain were considered for eligibility. For each category we further identified two sub-group according to the length of follow up: medium term and long term follow up (more than 3 years) respectively. Results: 46 papers, and 1242 patients, were included in the present investigation. When considering long term results DREZotomy provided favorable clinical outcomes in brachial plexus avulsion and spinal cord injury, in 60.8% and 55.8% of the cases respectively. Conversely, the success rate was 35.3% in phantom limb pain and 28.2% in post herpetic neuralgia. A poor clinical outcome was reported in over than 25% of the patients suffering from phantom limb pain, post herpetic neuralgia and spinal cord injury. The mean complications rate was 23.58%. While BPA and SCI patients presented stable improvement over time, good outcomes among PHN and PLP groups dropped by - 46.2%; and - 14.7% at long term follow up respectively. Conclusion: DREZotomy seems to be an effective treatment for chronic pain conditions, especially for brachial plexus avulsion, spinal cord injury and intractable cancer/post-radiation pain. According to the low level of evidence of the pertinent literature, further studies are strongly recommended, to better define potential benefits and limitations of this technique

引用

页数：9

共 65 条

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