Formal reductive addition of acetonitrile to aldehydes and ketones

被引：4

作者：

Muratov, Karim ^{[1
]}

Kuchuk, Ekaterina ^{[1
]}

Vellalath, Sreekumar ^{[2
]}

Afanasyev, Oleg I. ^{[1
]}

Moskovets, Alexei P. ^{[1
]}

Denisov, Gleb ^{[1
]}

Chusov, Denis ^{[1
]}

机构：

[1] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

[2] Baylor Univ, Dept Chem & Biochem, Waco, TX 76798 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 41期

基金：

俄罗斯科学基金会;

关键词：

CARBON-MONOXIDE; NUCLEOPHILIC ALLYLATION; CATALYZED CYANATION; ATOM-TRANSFER; ARYL HALIDES; AMINATION; NITRILES; ALPHA; CO; GRIGNARD;

D O I：

10.1039/c8ob01992d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and highly productive rhodium-catalyzed method for the synthesis of nitriles employing aldehydes or ketones, methyl cyanoacetate, water and carbon monoxide as starting materials has been developed. Simple rhodium chloride without any ligands can be used. The fine tuning of the substrate can lead to the activity higher than 5000 TON.

引用

页码：7693 / 7701

页数：9

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