Monitoring of 3D breast carcinoma cell culture using proton magnetic resonance imaging

被引：3

作者：

Bartusik, Dorota ^{[1
,2
]}

Tomanek, Boguslaw ^{[1
,2
,3
,4
]}

Fallone, Gino ^{[2
,4
]}

机构：

[1] Natl Res Council Canada, Inst Biodiagnost W, Calgary, AB T2N 4N1, Canada

[2] Cross Canc Inst, Dept Med Phys, Edmonton, AB T6G 1Z2, Canada

[3] Polish Acad Sci, Inst Nucl Phys, PL-31342 Krakow, Poland

[4] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 09期

关键词：

Breast cancer cells; Glycosaminoglycan; Magnetic resonance imaging; DRUG-DELIVERY; EXCHANGE; PROTEOGLYCANS; INVITRO;

D O I：

10.1007/s00044-009-9259-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We studied two human mammary carcinoma cell lines, MCF-7(NEO-4) HER-2 negative and MCF-7(HER-2) HER-2 positive, in three-dimensional culture. The aim of the study was to determine the glycosaminoglycan (GAG) concentration in breast cancer cell growth ex vivo. We found that GAG concentration produced by both breast cancer cell lines can be measured with high-field magnetic resonance imaging.

引用

页码：1153 / 1161

页数：9

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