Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies

被引:78
作者
Di Minno, Matteo Nicola Dario [1 ,2 ]
Ambrosino, Pasquale [1 ]
Ageno, Walter [3 ]
Rosendaal, Frits [4 ]
Di Minno, Giovanni [1 ]
Dentali, Francesco [3 ]
机构
[1] Univ Naples Federico II, Dept Clin Med & Surg, Reference Ctr Coagulat Disorders, I-80131 Naples, Italy
[2] IRCCS, Ctr Cardiol Monzino, Unit Cell & Mol Biol Cardiovasc Dis, Milan, Italy
[3] Univ Insubria, Dept Clin & Expt Med, Varese, Italy
[4] Leiden Univ, Dept Thrombosis & Hemostasis, Leiden, Netherlands
关键词
Antithrombin; Protein C; Protein S; Venous thromboembolism; PROTEIN-S DEFICIENCIES; INHERITED THROMBOPHILIA; ANTITHROMBIN DEFICIENCY; HEREDITARY DEFICIENCIES; FAMILIAL THROMBOPHILIA; PROSPECTIVE COHORT; THROMBOSIS; PREVALENCE; OUTPATIENTS; RECURRENCE;
D O I
10.1016/j.thromres.2015.03.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Natural anticoagulants deficiency (antithrombin [AT], protein C [PC], protein S [PS]) is a rare, but potent risk factor for venous thromboembolism (VTE). We performed a meta-analysis of observational studies evaluating the impact of inherited natural anticoagulants deficiency on VTE risk. Materials and Methods: Case-control and cohort studies evaluating the association of these abnormalities with VTE were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases. Results: Twenty-one studies were included in the analysis. Thirteen studies (3,452 cases and 11,562 controls) showed an increased risk of first VTE in AT deficient subjects compared to controls (OR: 16.26, 95% CI: 9.90-26.70; P < 0.00001). An increased risk of first VTE was also found in PC (11 studies, 2,554 cases and 9,355 controls; OR: 7.51, 95% CI: 3.21-17.52; P < 0.00001) and PS deficient patients (14 studies, 4,955 cases and 9,267 controls; OR: 5.37; 95% CI: 2.70-10.67; P < 0.00001) compared to controls. Evaluating the risk of VTE recurrence, we found a significant association with AT (4 studies, 142 cases and 1,927 controls; OR: 3.61; 95% CI: 1.46-8.95; P = 0.006) and with PC (2 studies, 80 cases and 546 controls; OR: 2.94; 95% CI: 1.43-6.04; P = 0.03), but not with PS deficiency (2 studies, 57 cases and 589 controls; OR: 2.52; 95% CI: 0.89-7.16; P = 0.08). Sensitivity and subgroup analyses confirmed these results. The association among natural anticoagulants deficiency and VTE was maximal for patients with unprovoked events. Conclusion: The VTE risk is increased in patients with natural anticoagulants deficiency, but additional studies are warranted to better assess the risk of VTE recurrence. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:923 / 932
页数:10
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