Genomic study of ossification of the posterior longitudinal ligament of the spine

被引：34

作者：

Ikegawa, Shiro ^{[1
]}

机构：

[1] RIKEN, Ctr Integrat Med Sci, Lab Bone & Joint Dis, Tokyo 1088639, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2014年 / 90卷 / 10期

关键词：

OPLL; susceptibility gene; genetics; linkage study; association study; genome-wide association study; NUCLEOTIDE PYROPHOSPHATASE GENE; BONE MORPHOGENETIC PROTEIN-2; BODY-MASS INDEX; CERVICAL-SPINE; JAPANESE POPULATION; RECEPTOR GENE; MOUSE MODEL; ASSOCIATION; SUSCEPTIBILITY; POLYMORPHISMS;

D O I：

10.2183/pjab.90.405

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease after the middle age. OPLL frequently causes serious neurological problems due to compression of the spinal cord and/or nerve roots. OPLL occurs in patients with monogenic metabolic diseases including rickets/osteomalacia and hypoparathyroidism; however most of OPLL is idiopathic and is considered as a multi-factorial (polygenic) disease influenced by genetic and environmental factors. Genomic studies for the genetic factors of OPLL have been conducted, mainly in Japan, including linkage and association studies. This paper reviews the recent progress in the genomic study of OPLL and comments on its future direction.

引用

页码：405 / 412

页数：8

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