The Effect of WT-1 Positivity on Survival Outcomes in Patients with High-grade Serous Epithelial Ovarian Cancer

Objective: This study investigated the significance WT-1 positivity on survival outcomes in patients with high-grade serous epithelial ovarian cancer (HGSOC). Methods: The medical records of the women who underwent surgery due to HGSOC between January 2015 and January 2020 were recorded. The patients' basic characteristic, serum tumor markers, disease stage, chemotherapeutic response, overall survival (OS), and progression-free survival (PFS) were recorded. WT-1 immune-staining was performed for all tissue samples. Results: The median age of the patients in the WT-1 (+) group was 59 (40-88) years, and it was 52 (41-78) in the WT-1 (-) group that was significantly higher in the WT-1 (+) group (p=0.007). The median Ca125 level was significantly higher in the WT-1 (+) group than the WT-1 (-) group [634 (7-12,580) vs. 274 (12-2,856), p=0.03]. The PFS [22 (8-54) vs. 12 (0-48), p<0.001] and OS [30 (8-56) vs. 16 (2-70), p<0.001] rates were significantly higher in the WT-1 (-) group than the WT-1 (+) group in Cox regression analysis, Ca125 was significantly associated with OS in univariate analysis (HR:1, 95% confidence interval:1-1.001, p=0.005). Conclusion: The patients with WT-1 positivity was associated with significantly shorter PFS and OS. Besides the patients in the WT-1 (+) group was older and had higher Ca125 levels than the WT-1 (-) group. The number of postmenopausal patients was higher in the WT-1 (+) group.