Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease

被引：97
|
作者：
Sato, S [1 ]
Mizuno, Y [1 ]
Hattori, N [1 ]
机构：
[1] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 1138421, Japan
来源：
NEUROLOGY | 2005年 / 64卷 / 06期
关键词：
D O I：
10.1212/01.WNL.0000154597.24838.6B
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
8-Hydroxydeoxyguanosine (8-OHdG) has been used to evaluate oxidative stress. The authors investigated urinary 8-OHdG levels in 72 patients with Parkinson disease (PD) and in normal and disease control groups. The mean urinary 8-OHdG increased with the stage of PD and was not influenced by the current dose of DOPA. Our results suggest that urinary 8-OHdG is a potentially useful biomarker for evaluating the progression of PD.
引用
收藏
页码：1081 / 1083
页数：3
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