Extending possible applications of an episodic-like memory task in rats

被引：18
作者：
Barbosa, Flavio Freitas [1 ]
de Oliveira Pontes, Isabella Maria [1 ]
Ribeiro, Alessandra Mussi [1 ]
Silva, Regina Helena [1 ]
机构：
[1] Univ Fed Rio Grande do Norte, Memory Studies Lab, Dept Physiol, BR-59072970 Natal, RN, Brazil
来源：
BEHAVIOURAL BRAIN RESEARCH | 2010年 / 215卷 / 02期
关键词：
Animal model; Episodic-like memory; Object recognition; Scopolamine; Rats; MEDIAL PREFRONTAL CORTEX; TEMPORAL-ORDER; RECOGNITION MEMORY; INTEGRATED MEMORY; C-FOS; FAMILIARITY; OBJECTS; LESIONS; PLACE; RECOLLECTION;
D O I：
10.1016/j.bbr.2009.11.028
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Recently, an object recognition episodic-like memory task was proposed in rodents. However, the short retention delay of the task narrows its applications. This study verifies whether this task can be evoked after 24 h. Additionally, the effect of a classical amnestic agent (scopolamine) on episodic-like memory consolidation was investigated. Rats showed increased exploration of old over recent objects and spent more time exploring displaced over stationary object. Both old over recent and displaced over stationary objects preferences were abolished by pos-training scopolamine administration (1 mg/kg i.p.), indicating impaired spatiotemporal retrieval. In conclusion, the object recognition task that accomplishes the what, where and when components of episodic-like memory in rats can persist for 24 h. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：326 / 331
页数：6
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