Discrete Self-Assembled Metallo-Foldamers with Heteroleptic Sequence Specificity

被引:20
作者
Preston, Dan [1 ]
机构
[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 2600, Australia
基金
澳大利亚研究理事会;
关键词
foldamer; helix; heteroleptic; palladium(II); self-assembly; CONFORMATIONAL CONTROL; BINDING; METALLOFOLDAMERS; RECOGNITION; DINUCLEAR; LIGANDS; STRANDS; DESIGN; SITE;
D O I
10.1002/anie.202108456
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Discrete and structurally diverse foldamer sequences are constructed in both natural and abiotic systems primarily using inert connectivity with irreversible organic covalent bonds, serving to preserve the identity of the sequence. The formation of sequences under thermodynamic control using labile coordination bonds would be attractive for synthetic ease and modular capability, but this presents issues regarding sequence preservation. Here is presented an approach integrating palladium(II) metal ions into the sequence itself, with fidelity maintained through use of complementary pairings of ligand arrangements at the metal centre. This is accomplished using sites of different denticity and/or hydrogen bonding capability. In this fashion, discrete and ordered metallo-sequences are formed as thermodynamic products in a single step, and these then fold into defined conformations due to pi-pi interactions between electron-rich and -poor aromatic regions of the combined componentry.
引用
收藏
页码:20027 / 20035
页数:9
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