Biological function and molecular mechanism of piRNA in cancer

被引：51

作者：

Chalbatani, Ghanbar Mahmoodi ^{[1
]}

Dana, Hassan ^{[3
]}

Memari, Feridon ^{[1
]}

Gharagozlou, Elahe ^{[1
]}

Ashjaei, Shirin ^{[2
]}

Kheirandish, Peyman ^{[1
]}

Marmari, Vahid ^{[3
]}

Mahmoudzadeh, Habibollah ^{[1
]}

Mozayani, Farnaz ^{[1
]}

Maleki, Ali Reza ^{[1
]}

Sadeghian, Ehsan ^{[1
]}

Nia, Elham Zainali ^{[3
]}

Miri, Seyed Rohollah ^{[1
]}

Nia, Neda Zainali ^{[4
]}

Rezaeian, Omid ^{[5
]}

Eskandary, Anahita ^{[5
]}

Razavi, Narges ^{[6
]}

Shirkhoda, Mohammad ^{[1
]}

Rouzbahani, Fatemeh Nouri ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Canc Inst Iran, Canc Res Ctr, Tehran, Iran

[2] Islamic Azad Univ, Tehran Branch, Dept Paramed Sci, Tehran, Iran

[3] Islamic Azad Univ, Damghan Branch, Dept Biol, Damghan, Iran

[4] Islamic Azad Univ, Tonekabon Branch, Dept Biol, Tonekabon, Iran

[5] NourDanesh Inst Higher Educ, Dept Biol, Esfahan, Iran

[6] Shahid Beheshti Univ Med Sci, Tehran, Iran

来源：

PRACTICAL LABORATORY MEDICINE | 2019年 / 13卷

关键词：

Cancer; PiRNA; Noncoding RNA; Gene silencing; RNAi; PIWI-INTERACTING RNAS; NONCODING RNAS; GASTRIC-CANCER; CELL MAINTENANCE; EXPRESSION; STATISTICS; BIOGENESIS; PROTEINS; GERMLINE; MICRORNA;

D O I：

10.1016/j.plabm.2018.e00113

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

引用

页数：6

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