SYNTHESIS AND CHARACTERIZATION OF DRUG - MINERAL CLAY HYBRID MATERIALS FOR BIOMEDICAL APPLICATIONS AS DRUG DELIVERY SYSTEMS - PART I

In order to obtain a drug delivery system used in tumoral treatment, this study presents the synthesis of mineral clay /antitumor drug hybrid materials. There were used three types of mineral phases with different structural characteristics as matrix and epirubicin, fludarabine, gemcitabine as active substances. The obtaining process was performed by mixing an aqueous solution of the drugs with the swelled clay. For the active substances incorporation, drug-solutions were heated and added slowly in clays suspensions (at 60 degrees C, using magnetic stirring - 350 rpm). The dried hybrid materials were obtained after the separation was performed by centrifugation of cooled suspension. The synthesized hybrid materials were characterized using different experimental techniques as Xray diffraction, thermal analysis, scanning electron microscopy etc.. The characterization gave information about the proper interlayer intercalation of cytostatic, the good adsorption of drug into the matrix and the microstructure.