Recombinant Influenza Vaccines: Saviors to Overcome Immunodominance

被引：17

作者：

Mathew, Nimitha R. ^{[1
]}

Angeletti, Davide ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Microbiol & Immunol, Inst Biomed, Gothenburg, Sweden

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 10卷

基金：

瑞典研究理事会;

关键词：

influenza A virus; immunodominance; vaccines; B cells; antibodies; RECEPTOR-BINDING SITE; HUMAN MONOCLONAL-ANTIBODY; CONSERVED NEUTRALIZING EPITOPE; VIRUS HEMAGGLUTININ; GLOBULAR HEAD; A VIRUS; B VIRUS; REACTIVE ANTIBODIES; SEASONAL INFLUENZA; ANTIGENIC VARIANTS;

D O I：

10.3389/fimmu.2019.02997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been almost a decade since the 2009 influenza A virus pandemic hit the globe causing significant morbidity and mortality. Nonetheless, annual influenza vaccination, which elicits antibodies mainly against the head region of influenza hemagglutinin (HA), remains as the mainstay to combat and reduce symptoms of influenza infection. Influenza HA is highly antigenically variable, thus limiting vaccine efficacy. In addition, the variable HA head occupies the upper strata of the immunodominance hierarchy, thereby clouding the antibody response toward subdominant epitopes, which are usually conserved across different influenza strains. Isolation of monoclonal antibodies from individuals recognizing such epitopes has facilitated the development of recombinant vaccines that focus the adaptive immune response toward conserved, protective targets. Here, we review some significant leaps in recombinant vaccine development, which could possibly help to overcome B cell and antibody immunodominance and provide heterosubtypic immunity to influenza A virus.

引用

页数：10

共 153 条

[1] Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies [J].

Adachi, Yu ;

Tonouchi, Keisuke ;

Nithichanon, Arnone ;

Kuraoka, Masayuki ;

Watanabe, Akiko ;

Shinnakasu, Ryo ;

Asanuma, Hideki ;

Ainai, Akira ;

Ohmi, Yusuke ;

Yamamoto, Takuya ;

Ishii, Ken J. ;

Hasegawa, Hideki ;

Takeyama, Haruko ;

Lertmemongkolchai, Ganjana ;

Kurosaki, Tomohiro ;

Ato, Manabu ;

Kelsoe, Garnett ;

Takahashi, Yoshimasa .

NATURE COMMUNICATIONS, 2019, 10 (1)

[2] LOCATION OF ANTIGENIC SITES ON THE 3-DIMENSIONAL STRUCTURE OF THE INFLUENZA N2 VIRUS NEURAMINIDASE [J].

AIR, GM ;

ELS, MC ;

BROWN, LE ;

LAVER, WG ;

WEBSTER, RG .

VIROLOGY, 1985, 145 (02) :237-248

[3] Broadened immunity and protective responses with emulsion-adjuvanted H5 COBRA-VLP vaccines [J].

Allen, James D. ;

Owino, Simon ;

Carter, Donald M. ;

Crevar, Corey J. ;

Reese, Valerie A. ;

Fox, Christopher B. ;

Coler, Rhea N. ;

Reed, Steven G. ;

Baldwin, Susan L. ;

Ross, Ted M. .

VACCINE, 2017, 35 (38) :5209-5216

[4] Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza [J].

Anderson, Ane Marie ;

Baranowska-Hustad, Marta ;

Braathen, Ranveig ;

Grodeland, Gunnveig ;

Bogen, Bjarne .

JOURNAL OF IMMUNOLOGY, 2018, 200 (06) :2057-2066

[5] Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain (vol 7, 2017) [J].

Anderson, Christopher S. ;

Ortega, Sandra ;

Chaves, Francisco A. ;

Clark, Amelia M. ;

Yang, Hongmei ;

Topham, David J. ;

DeDiego, Marta L. .

SCIENTIFIC REPORTS, 2018, 8

[6] Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin [J].

Andrews, Sarah F. ;

Chambers, Michael J. ;

Schramm, Chaim A. ;

Plyler, Jason ;

Raab, Julie E. ;

Kanekiyo, Masaru ;

Gillespie, Rebecca A. ;

Ransier, Amy ;

Darko, Sam ;

Hu, Jianfei ;

Chen, Xuejun ;

Yassine, Hadi M. ;

Boyington, Jeffrey C. ;

Crank, Michelle C. ;

Chen, Grace L. ;

Coates, Emily ;

Mascola, John R. ;

Douek, Daniel C. ;

Graham, Barney S. ;

Ledgerwood, Julie E. ;

McDermott, Adrian B. .

IMMUNITY, 2019, 51 (02) :398-+

[7] Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans [J].

Andrews, Sarah F. ;

Joyce, M. Gordon ;

Chambers, Michael J. ;

Gillespie, Rebecca A. ;

Kanekiyo, Masaru ;

Leung, Kwanyee ;

Yang, Eun Sung ;

Tsybovsky, Yaroslav ;

Wheatley, Adam K. ;

Crank, Michelle C. ;

Boyington, Jeffrey C. ;

Prabhakaran, Madhu S. ;

Narpala, Sandeep R. ;

Chen, Xuejun ;

Bailer, Robert T. ;

Chen, Grace ;

Coates, Emily ;

Kwong, Peter D. ;

Koup, Richard A. ;

Mascola, John R. ;

Graham, Barney S. ;

Ledgerwood, Julie E. ;

McDermott, Adrian B. .

SCIENCE IMMUNOLOGY, 2017, 2 (13)

[8] Immune history profoundly affects broadly protective B cell responses to influenza [J].

Andrews, Sarah F. ;

Huang, Yunping ;

Kaur, Kaval ;

Popova, Lyubov I. ;

Ho, Irvin Y. ;

Pauli, Noel T. ;

Dunand, Carole J. Henry ;

Taylor, William M. ;

Lim, Samuel ;

Huang, Min ;

Qu, Xinyan ;

Lee, Jane-Hwei ;

Salgado-Ferrer, Marlene ;

Krammer, Florian ;

Palese, Peter ;

Wrammert, Jens ;

Ahmed, Rafi ;

Wilson, Patrick C. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (316)

[9] Outflanking immunodominance to target subdominant broadly neutralizing epitopes [J].

Angeletti, Davide ;

Kosik, Ivan ;

Santos, Jefferson J. S. ;

Yewdell, William T. ;

Boudreau, Carolyn M. ;

Mallajosyula, Vamsee V. A. ;

Mankowski, Madeleine C. ;

Chambers, Michael ;

Prabhakaran, Madhu ;

Hickman, Heather D. ;

McDermott, Adrian B. ;

Alter, Galit ;

Chaudhuri, Jayanta ;

Yewdell, Jonathan W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (27) :13474-13479

[10] Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Outflanking Antibody Immunodominance on the Road to Universal Influenza Vaccination [J].

Angeletti, Davide ;

Yewdell, Jonathan W. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2018, 10 (07)

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