ANALYSIS AND APPROXIMATION OF STOCHASTIC NERVE AXON EQUATIONS

被引:8
作者
Sauer, Martin [1 ]
Stannat, Wilhelm [1 ,2 ]
机构
[1] Tech Univ Berlin, Inst Math, Str 17 Juni 136, D-10623 Berlin, Germany
[2] Bernstein Ctr Computat Neurosci, Philipp Str 13, D-10115 Berlin, Germany
关键词
Stochastic reaction diffusion equations; finite difference approximation; Hodgkin-Huxley equations; FitzHugh-Nagumo equations; conductance based neuronal models; PARTIAL-DIFFERENTIAL-EQUATIONS; DRIVEN;
D O I
10.1090/mcom/3068
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
We consider spatially extended conductance based neuronal models with noise described by a stochastic reaction diffusion equation with additive noise coupled to a control variable with multiplicative noise but no diffusion. We only assume a local Lipschitz condition on the non-linearities together with a certain physiologically reasonable monotonicity to derive crucial L-infinity-bounds for the solution. These play an essential role in both the proof of existence and uniqueness of solutions as well as the error analysis of the finite difference approximation in space. We derive explicit error estimates, in particular, a pathwise convergence rate of root 1/n- and a strong convergence rate of 1/n in special cases. As applications, the Hodgkin-Huxley and FitzHugh-Nagumo systems with noise are considered.
引用
收藏
页码:2457 / 2481
页数:25
相关论文
共 29 条
[1]  
Andersson A., 2012, ARXIV12125564
[2]  
[Anonymous], ENCY MATH APPL
[3]  
[Anonymous], 1969, BIOL ENG
[4]   Mean-field description and propagation of chaos in networks of Hodgkin-Huxley and FitzHugh-Nagumo neurons [J].
Baladron, Javier ;
Fasoli, Diego ;
Faugeras, Olivier ;
Touboul, Jonathan .
JOURNAL OF MATHEMATICAL NEUROSCIENCE, 2012, 2
[5]   Full discretization of the stochastic Burgers equation with correlated noise [J].
Bloemker, Dirk ;
Kamrani, Minoo ;
Hosseini, S. Mohammad .
IMA JOURNAL OF NUMERICAL ANALYSIS, 2013, 33 (03) :825-848
[6]  
Ermentrout G. B., 2010, INTERDISCIPLINARY AP, V35
[7]   IMPULSES AND PHYSIOLOGICAL STATES IN THEORETICAL MODELS OF NERVE MEMBRANE [J].
FITZHUGH, R .
BIOPHYSICAL JOURNAL, 1961, 1 (06) :445-&
[8]   Strong solutions for stochastic partial differential equations of gradient type [J].
Gess, Benjamin .
JOURNAL OF FUNCTIONAL ANALYSIS, 2012, 263 (08) :2355-2383
[9]   The What and Where of Adding Channel Noise to the Hodgkin-Huxley Equations [J].
Goldwyn, Joshua H. ;
Shea-Brown, Eric .
PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (11)
[10]   Rate of Convergence of Space Time Approximations for Stochastic Evolution Equations [J].
Gyoengy, Istvan ;
Millet, Annie .
POTENTIAL ANALYSIS, 2009, 30 (01) :29-64