Polyunsaturated fatty acid regulation of gene expression

被引：180

作者：

Sessler, AM

Ntambi, JM ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

来源：

JOURNAL OF NUTRITION | 1998年 / 128卷 / 06期

关键词：

polyunsaturated fatty acids; peroxisome proliferator responsive element; adipocyte; gene regulation;

D O I：

10.1093/jn/128.6.923

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

For the past three decades, polyunsaturated fatty acids (PUFA) have been recognized as important energy sources and membrane components, PUFA also play key roles in many cellular events, such as gene regulation. Most recently, research has focused on identifying the mechanisms by which PUFA modulate gene transcription, mRNA stability and cellular differentiation. It is the purpose of this review to examine the effects of PUFA on gene expression in lipogenic as well as other tissues. Because the (n-3) and (n-6) series of PUFA are intimately involved in gene regulation, they will be the focus of review. The effects of other fatty acid families on gene expression are reviewed elsewhere.

引用

收藏

页码：923 / 926

页数：4

相关论文

共 50 条

[21] Polyunsaturated fatty acid inhibition of fatty acid synthase transcription is independent of PPAR activation [J].

Clarke, SD ;

Turini, M ;

Jump, DB ;

Abraham, S ;

Reedy, M .

ZEITSCHRIFT FUR ERNAHRUNGSWISSENSCHAFT, 1998, 37 :14-20

[22] Insulin/glucose-, pyruvate- and polyunsaturated fatty acid-responsive region(s) of rat fatty acid synthase gene promoter [J].

Fukuda, H ;

Iritani, N ;

Katsurada, A ;

Noguchi, T .

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1996, 38 (05) :987-996

[23] The Myristic Acid:Docosahexaenoic Acid Ratio Versus the n-6 Polyunsaturated Fatty Acid:n-3 Polyunsaturated Fatty Acid Ratio as Nonalcoholic Fatty Liver Disease Biomarkers [J].

Antunes, Marina Masetto ;

Godoy, Guilherme ;

Curi, Rui ;

Visentainer, Jesui Vergilio ;

Bazotte, Roberto Barbosa .

METABOLIC SYNDROME AND RELATED DISORDERS, 2022, 20 (02) :69-78

[24] Metabolic engineering of plants for polyunsaturated fatty acid production [J].

Truksa, Martin ;

Vrinten, Patricia ;

Qiu, Xiao .

MOLECULAR BREEDING, 2009, 23 (01) :1-11

[25] Metabolic engineering of plants for polyunsaturated fatty acid production [J].

Martin Truksa ;

Patricia Vrinten ;

Xiao Qiu .

Molecular Breeding, 2009, 23 :1-11

[26] Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice [J].

Nakajima, Takero ;

Yang, Yang ;

Lu, Yu ;

Kamijo, Yuji ;

Yamada, Yosuke ;

Nakamura, Kozo ;

Koyama, Masahiro ;

Yamaguchi, Shohei ;

Sugiyama, Eiko ;

Tanaka, Naoki ;

Aoyama, Toshifumi .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 242 (03) :229-239

[27] Polyunsaturated fatty acid intake and blood pressure in adolescents [J].

O'Sullivan, T. A. ;

Bremner, A. P. ;

Beilin, L. J. ;

Ambrosini, G. L. ;

Mori, T. A. ;

Huang, R. C. ;

Oddy, W. H. .

JOURNAL OF HUMAN HYPERTENSION, 2012, 26 (03) :178-187

[28] Polyunsaturated fatty acid status and aggression in cocaine addicts [J].

Buydens-Branchey, L ;

Branchey, M ;

McMakin, DL ;

Hibbeln, JR .

DRUG AND ALCOHOL DEPENDENCE, 2003, 71 (03) :319-323

[29] Contribution of Diet and Genes to Polyunsaturated Fatty Acid Composition [J].

Tanaka T. .

Current Cardiovascular Risk Reports, 2011, 5 (1) :45-51

[30] STUDY ON THE POLYUNSATURATED FATTY ACID CHANGES IN OVIDUCTUS RANAE [J].

Sun, Jingmeng ;

Wang, Zhuoming ;

Tong, Lumei ;

Zhang, Weiyu .

FRESENIUS ENVIRONMENTAL BULLETIN, 2020, 29 (12) :10567-10574

← 1 2 3 4 5 →