Handling founder inbreeding in forensic kinship analysis

被引:6
作者
Vigeland, Magnus D. [1 ]
Egeland, Thore [2 ]
机构
[1] Univ Oslo, Dept Med Genet, Oslo, Norway
[2] Norwegian Univ Life Sci, Fac Chem Biotechnol & Food Sci, As, Norway
关键词
Kinship; Relatedness; Founder inbreeding; Likelihood ratio; Exclusion power; POWER;
D O I
10.1016/j.fsigss.2019.10.175
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We propose an extension of standard methods for computing pedigree likelihoods, in which pedigree founders are allowed to be inbred. Support for inbred founders is implemented in the forrel R package for forensic pedigree analysis. This enables for the first time background inbreeding to be modelled and studied in a variety of applications, including likelihood ratios, exclusion probabilities, relatedness inference and simulation studies. We illustrate these advances through two study cases.
引用
收藏
页码:780 / 781
页数:2
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