Key considerations for LC-MS analysis of protein biotherapeutics in tissues

被引：8
作者：
Fu, Wei [1 ,2 ,3 ]
An, Bo [2 ,3 ]
Wang, Xue [2 ,3 ]
Qu, Jun [2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharm, Tongji Hosp, Wuhan, Hubei, Peoples R China
[2] Univ Buffalo State Univ New York, Dept Pharmaceut Sci, Buffalo, NY 14260 USA
[3] New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14203 USA
来源：
BIOANALYSIS | 2017年 / 9卷 / 18期
关键词：
antigen; biotherapeutics; LC-MS; tissue bioanalysis; ORTHOGONAL ARRAY OPTIMIZATION; QUANTIFICATION; ACCURATE; DRUG; BIOANALYSIS; ANTIBODIES; MS/MS;
D O I：
10.4155/bio-2017-0122
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：1349 / 1352
页数：4
相关论文
共 20 条
[1]  
An B, 2016, AM SOC MASS SPECTR A
[2]  
An B, 2016, AM SOC MASS SPECTR A, V5
[3]  
An B, ANAL CHEM, V87
[4]   SCX charge state selective separation of tryptic peptides combined with 2D-RP-HPLC allows for detailed proteome mapping [J].
Betancourt, Lazaro H. ;
De Bock, Pieter-Jan ;
Staes, An ;
Timmerman, Evy ;
Perez-Riverol, Yasset ;
Sanchez, Aniel ;
Besada, Vladimir ;
Javier Gonzalez, Luis ;
Vandekerckhove, Joel ;
Gevaert, Kris .
JOURNAL OF PROTEOMICS, 2013, 91 :164-171
[5]   A Rapid, Reproducible, On-the-Fly Orthogonal Array Optimization Method for Targeted Protein Quantification by LC/MS and Its Application for Accurate and Sensitive Quantification of Carbonyl Reductases in Human Liver [J].
Cao, Jin ;
Covarrubias, Vanessa M. ;
Straubinger, Robert M. ;
Wang, Hao ;
Duan, Xiaotao ;
Yu, Haoying ;
Qu, Jun ;
Blanco, Javier G. .
ANALYTICAL CHEMISTRY, 2010, 82 (07) :2680-2689
[6]   Antibody Drug-Target Engagement Measurement in Tissue Using Quantitative Affinity Extraction Liquid Chromatography Mass Spectrometry: Method Development and Qualification [J].
Ciccimaro, Eugene ;
Zhu, Yongxin ;
Ostanin, Dmitry ;
Suchard, Suzanne ;
MacGuire, Jamus ;
Xiao, Qing ;
Dongre, Ashok ;
Chimalakonda, Anjaneya ;
Olah, Timothy ;
Shipkova, Petia .
ANALYTICAL CHEMISTRY, 2017, 89 (09) :5115-5123
[7]   High-Throughput Method Development for Sensitive, Accurate, and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Tissues Using Orthogonal Array Optimization and Nano Liquid Chromatography/Selected Reaction Monitoring Mass Spectrometry [J].
Duan, Xiaotao ;
Abuqayyas, Lubna ;
Dai, Lipeng ;
Balthasar, Joseph P. ;
Qu, Jun .
ANALYTICAL CHEMISTRY, 2012, 84 (10) :4373-4382
[8]   Assessments of Antibody Biodistribution [J].
Glassman, Patrick M. ;
Abuqayyas, Lubna ;
Balthasar, Joseph P. .
JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 55 (03) :S29-S38
[9]   Fully Validated LC-MS/MS Assay for the Simultaneous Quantitation of Coadministered Therapeutic Antibodies in Cynomolgus Monkey Serum [J].
Jiang, Hao ;
Zeng, Jianing ;
Titsch, Craig ;
Voronin, Kimberly ;
Akinsanya, Billy ;
Luo, Linlin ;
Shen, Hongwu ;
Desai, Dharmesh D. ;
Allentoff, Alban ;
Aubry, Anne-Francoise ;
DeSilva, Binodh S. ;
Arnold, Mark E. .
ANALYTICAL CHEMISTRY, 2013, 85 (20) :9859-9867
[10]   Applications of low-flow LC-SRM for the analysis of large molecules in pharmaceutical R&D [J].
Lassman, Michael E. ;
Fernandez-Metzler, Carmen .
BIOANALYSIS, 2014, 6 (13) :1859-1867
12