Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys

被引：39
作者：
Etemad-Moghadam, B
Karlsson, GB
Halloran, M
Sun, Y
Schenten, D
Fernandes, M
Letvin, NL
Sodroski, J
机构：
[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA USA
[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
JOURNAL OF VIROLOGY | 1998年 / 72卷 / 10期
关键词：
D O I：
10.1128/JVI.72.10.8437-8445.1998
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein epitopes recognized by neutralizing antibodies from monkeys recently infected by molecularly cloned simian-human immunodeficiency virus (SHIV) variants. The early neutralizing antibody response in each infected animal was directed mainly against a single epitope. This primary neutralizing epitope, however, differed among individual monkeys infected by identical viruses. Two such neutralization epitopes were determined by sequences in the V2 and V3 loops of the gp120 envelope glycoprotein, while a third neutralization epitope, apparently discontinuous, was determined by both V2 and V3 sequences. These results indicate that the early neutralizing antibody response in SHIV-infected monkeys is monospecific and directed against epitopes composed of the gp120 V2 and V3 variable loops.
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收藏
页码：8437 / 8445
页数：9
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