Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic

被引:30
作者
Kaur, Rajwinder [1 ]
Sood, Ankita [1 ]
Lang, Damanpreet Kaur [1 ]
Arora, Rashmi [1 ]
Kumar, Neeraj [2 ]
Diwan, Vishal [3 ]
Saini, Balraj [1 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India
[2] Natl Inst Pharmaceut Educ & Res NIPER, Dept Regulatory Affairs, Hyderabad, India
[3] Univ Queensland, Ctr Chron Dis, Brisbane, Qld, Australia
关键词
Natural products; Ferulic acid; Multi-target therapeutics; Alzheimer's disorders; Cancer; Viral infections; H1N1; virus; POTENTIAL MULTIFUNCTIONAL AGENTS; OXIDATIVE STRESS; IN-VITRO; ISOFERULIC ACID; ETHYL-ESTER; SKIN; ANTIOXIDANT; COMBINATION; DERIVATIVES; DELIVERY;
D O I
10.2174/1568026622666220117105740
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Nature has provided therapeutic substances for millennia, with many valuable medications derived from plant sources. Multitarget drugs become essential in the management of various disorders, including hepatic disorders, neurological disorders, diabetes, and carcinomas. Ferulic acid is a significant potential therapeutic agent, which is easily available at low cost, possesses a low toxicity profile, and has minimum side effects. Ferulic acid exhibits various therapeutic actions by modulation of various signal transduction pathways such as Nrf2, p38, and mTOR. The actions exhibited by ferulic acid include anti-apoptosis, antioxidant, anti-inflammatory, antidiabetic, anticarcinogenic, hepatoprotection, cardioprotection, activation of transcriptional factors, expression of genes, regulation of enzyme activity, and neuroprotection, which further help in treating various pathophysiological conditions such as cancer, skin diseases, brain disorders, diabetes, Parkinson's disease, Alzheimer's disease, hypoxia, hepatic disorders, H1N1 flu, and viral infections. The current review focuses on the significance of natural products as sources of multitarget compounds, and a primary focus has been made on ferulic acid and its mechanism, role, and protective action in various ailments.
引用
收藏
页码:347 / 365
页数:19
相关论文
共 115 条
  • [1] Microbial Natural Products in Drug Discovery
    Abdel-Razek, Ahmed S.
    El-Naggar, Mehrez E.
    Allam, Ahmed
    Morsy, Osama M.
    Othman, Sarah I.
    [J]. PROCESSES, 2020, 8 (04)
  • [2] Adeyemi O.S., 2019, OPEN BIOCH J, V13, P13, DOI [10.2174, 10.2174/1874091X01913010013, DOI 10.2174/1874091X01913010013]
  • [3] al Jitan S., 2018, Studies in Natural Products Chemistry, V58, P389, DOI DOI 10.1016/B978-0-444-64056-7.00013-1
  • [4] Herbal Cosmetics and Novel Drug Delivery Systems
    Algin Yapar, Evren
    [J]. INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2017, 51 (03) : S152 - S158
  • [5] Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX
    Aneja, Babita
    Queen, Aarfa
    Khan, Parvez
    Shamsi, Farheen
    Hussain, Afzal
    Hasan, Phool
    Rizvi, M. Moshahid A.
    Daniliuc, Constantin G.
    Alajmi, Mohamed F.
    Mohsin, Mohd
    Hassan, Md Imtaiyaz
    Abid, Mohammad
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (09)
  • [6] Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6-hydroxydopamine lesioned rats
    Anis, Ehraz
    Zafeer, Mohd Faraz
    Firdaus, Fakiha
    Islam, Shireen Naaz
    Khan, Azka Anees
    Ali, Asif
    Hossain, M. Mobarak
    [J]. PHYTOTHERAPY RESEARCH, 2020, 34 (01) : 214 - 226
  • [7] [Anonymous], 2014, FINAL RECOMMENDATION
  • [8] Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin
    Assouline, Sarit
    Culjkovic, Biljana
    Cocolakis, Eftihia
    Rousseau, Caroline
    Beslu, Nathalie
    Amri, Abdellatif
    Caplan, Stephen
    Leber, Brian
    Roy, Denis-Claude
    Miller, Wilson H., Jr.
    Borden, Katherine L. B.
    [J]. BLOOD, 2009, 114 (02) : 257 - 260
  • [9] Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties
    Azam, S
    Hadi, N
    Khan, NU
    Hadi, SM
    [J]. TOXICOLOGY IN VITRO, 2004, 18 (05) : 555 - 561
  • [10] Ferulic acid and its therapeutic potential as a hormetin for age-related diseases
    Barone, Eugenio
    Calabrese, Vittorio
    Mancuso, Cesare
    [J]. BIOGERONTOLOGY, 2009, 10 (02) : 97 - 108