GATA Switches as Developmental Drivers

被引：224

作者：

Bresnick, Emery H. ^{[1
,2
]}

Lee, Hsiang-Ying ^{[1
,2
]}

Fujiwara, Tohru ^{[1
,2
]}

Johnson, Kirby D. ^{[1
,2
]}

Keles, Sunduz ^{[3
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Div Hematol Oncol,Dept Pharmacol, Madison, WI 53705 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Dept Med, Madison, WI 53705 USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53706 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 41期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR GATA-1; CHROMATIN DOMAIN ACTIVATION; ZINC-FINGER PROTEIN; DNA-BINDING; GENE-EXPRESSION; ERYTHROID DEVELOPMENT; DEPENDENT REGULATION; HEMATOPOIETIC-CELLS; FACTOR INTERPLAY; GLOBIN LOCUS;

D O I：

10.1074/jbc.R110.159079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.

引用

页码：31087 / 31093

页数：7

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