GATA Switches as Developmental Drivers

被引：221
作者：
Bresnick, Emery H. [1 ,2 ]
Lee, Hsiang-Ying [1 ,2 ]
Fujiwara, Tohru [1 ,2 ]
Johnson, Kirby D. [1 ,2 ]
Keles, Sunduz [3 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Div Hematol Oncol,Dept Pharmacol, Madison, WI 53705 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Dept Med, Madison, WI 53705 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53706 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 41期
基金：
美国国家卫生研究院;
关键词：
TRANSCRIPTION FACTOR GATA-1; CHROMATIN DOMAIN ACTIVATION; ZINC-FINGER PROTEIN; DNA-BINDING; GENE-EXPRESSION; ERYTHROID DEVELOPMENT; DEPENDENT REGULATION; HEMATOPOIETIC-CELLS; FACTOR INTERPLAY; GLOBIN LOCUS;
D O I：
10.1074/jbc.R110.159079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.
引用
收藏
页码：31087 / 31093
页数：7
相关论文
共 100 条
  • [41] BRG1 requirement for long-range interaction of a locus control region with a downstream promoter
    Kim, Shin-Il
    Bultman, Scott J.
    Kiefer, Christine M.
    Dean, Ann
    Bresnick, Emery H.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) : 2259 - 2264
  • [42] DNA-BINDING SPECIFICITIES OF THE GATA TRANSCRIPTION FACTOR FAMILY
    KO, LJ
    ENGEL, JD
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (07) : 4011 - 4022
  • [43] GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene
    Kobayashi-Osaki, M
    Ohneda, O
    Suzuki, N
    Minegishi, N
    Yokomizo, T
    Takahashi, S
    Lim, KC
    Engel, JD
    Yamamoto, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (16) : 7005 - 7020
  • [44] GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Kouros-Mehr, Hosein
    Slorach, Euan M.
    Sternlicht, Mark D.
    Werb, Zena
    [J]. CELL, 2006, 127 (05) : 1041 - 1055
  • [45] Controlling Hematopoiesis through Sumoylation-Dependent Regulation of a GATA Factor
    Lee, Hsiang-Ying
    Johnson, Kirby D.
    Fujiwara, Tohru
    Boyer, Meghan E.
    Kim, Shin-Il
    Bresnick, Emery H.
    [J]. MOLECULAR CELL, 2009, 36 (06) : 984 - 995
  • [46] LEE ME, 1991, J BIOL CHEM, V266, P16188
  • [47] LEONARD M, 1993, BLOOD, V82, P1071
  • [48] Context-dependent regulation of GATA-1 by friend of GATA-1
    Letting, DL
    Chen, YY
    Rakowski, C
    Reedy, S
    Blobel, GA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (02) : 476 - 481
  • [49] Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1
    Letting, DL
    Rakowski, C
    Weiss, MJ
    Blobel, GA
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (04) : 1334 - 1340
  • [50] Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system
    Lim, KC
    Lakshmanan, G
    Crawford, SE
    Gu, Y
    Grosveld, F
    Engel, JD
    [J]. NATURE GENETICS, 2000, 25 (02) : 209 - 212
12345678910