GATA Switches as Developmental Drivers

被引：221
作者：
Bresnick, Emery H. [1 ,2 ]
Lee, Hsiang-Ying [1 ,2 ]
Fujiwara, Tohru [1 ,2 ]
Johnson, Kirby D. [1 ,2 ]
Keles, Sunduz [3 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Div Hematol Oncol,Dept Pharmacol, Madison, WI 53705 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Dept Med, Madison, WI 53705 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53706 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 41期
基金：
美国国家卫生研究院;
关键词：
TRANSCRIPTION FACTOR GATA-1; CHROMATIN DOMAIN ACTIVATION; ZINC-FINGER PROTEIN; DNA-BINDING; GENE-EXPRESSION; ERYTHROID DEVELOPMENT; DEPENDENT REGULATION; HEMATOPOIETIC-CELLS; FACTOR INTERPLAY; GLOBIN LOCUS;
D O I：
10.1074/jbc.R110.159079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.
引用
收藏
页码：31087 / 31093
页数：7
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