GATA Switches as Developmental Drivers

被引：221
作者：
Bresnick, Emery H. [1 ,2 ]
Lee, Hsiang-Ying [1 ,2 ]
Fujiwara, Tohru [1 ,2 ]
Johnson, Kirby D. [1 ,2 ]
Keles, Sunduz [3 ]
机构：
[1] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Div Hematol Oncol,Dept Pharmacol, Madison, WI 53705 USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Paul Carbone Comprehens Canc Ctr, Dept Med, Madison, WI 53705 USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53706 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 41期
基金：
美国国家卫生研究院;
关键词：
TRANSCRIPTION FACTOR GATA-1; CHROMATIN DOMAIN ACTIVATION; ZINC-FINGER PROTEIN; DNA-BINDING; GENE-EXPRESSION; ERYTHROID DEVELOPMENT; DEPENDENT REGULATION; HEMATOPOIETIC-CELLS; FACTOR INTERPLAY; GLOBIN LOCUS;
D O I：
10.1074/jbc.R110.159079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.
引用
收藏
页码：31087 / 31093
页数：7
相关论文
共 100 条
  • [21] Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
    Fujiwara, Y
    Chang, AN
    Williams, AM
    Orkin, SH
    [J]. BLOOD, 2004, 103 (02) : 583 - 585
  • [22] Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1
    Fujiwara, Y
    Browne, CP
    Cunniff, K
    Goff, SC
    Orkin, SH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) : 12355 - 12358
  • [23] Loss of Gata1 but not Gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos
    Galloway, JL
    Wingert, RA
    Thisse, C
    Thisse, B
    Zon, LI
    [J]. DEVELOPMENTAL CELL, 2005, 8 (01) : 109 - 116
  • [24] FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis
    Gao, Zhiguang
    Huang, Zan
    Olivey, Harold E.
    Gurbuxani, Sandeep
    Crispino, John D.
    Svensson, Eric C.
    [J]. EMBO JOURNAL, 2010, 29 (02) : 457 - 468
  • [25] Goodman RH, 2000, GENE DEV, V14, P1553
  • [26] GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    Grass, JA
    Boyer, ME
    Pal, SM
    Wu, J
    Weiss, MJ
    Bresnick, EH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) : 8811 - 8816
  • [27] Distinct functions of dispersed GATA factor complexes at an endogenous gene locus
    Grass, Jeffrey A.
    Jing, Huie
    Kim, Shin-Il
    Martowicz, Melissa L.
    Pal, Saumen
    Blobel, Gerd A.
    Bresnick, Emery H.
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (19) : 7056 - 7067
  • [28] Using the zebrafish model to study GATA transcription factors
    Heicklen-Klein, A
    McReynolds, LJ
    Evans, T
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (01) : 95 - 106
  • [29] Essential and instructive roles of GATA factors in eosinophil development
    Hirasawa, R
    Shimizu, R
    Takahashi, S
    Osawa, M
    Takayanagi, S
    Kato, Y
    Onodera, M
    Minegishi, N
    Yamamoto, M
    Fukao, K
    Taniguchi, H
    Nakauchi, H
    Iwama, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (11) : 1379 - 1386
  • [30] FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1
    Hong, W
    Nakazawa, M
    Chen, YY
    Kori, R
    Vakoc, CR
    Rakowski, C
    Blobel, GA
    [J]. EMBO JOURNAL, 2005, 24 (13) : 2367 - 2378
12345678910