Plasma haloperidol and reduced haloperidol concentrations in a geriatric population

被引：16

作者：

Chang, WH

Jann, MW

Chiang, TS

Lin, HN

Hu, WH

Chien, CP

机构：

[1] NATL TAIWAN UNIV,COLL MED,DEPT PSYCHIAT,TAIPEI,TAIWAN

[2] TAIPEI MUNICIPAL KWANGTZU PO AI,TAIPEI,TAIWAN

[3] MERCER UNIV,SO SCH PHARM,MACON,GA 31207

来源：

NEUROPSYCHOBIOLOGY | 1996年 / 33卷 / 01期

关键词：

haloperidol; reduced haloperidol; plasma levels; geriatrics; DEBRISOQUINE HYDROXYLATION PHENOTYPE; PHARMACOKINETICS; DISPOSITION;

D O I：

10.1159/000119242

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Haloperidol (HL) and reduced haloperidol (RH) plasma concentrations were measured in geriatric patients (n = 45) and schizophrenic patients (n = 8). In the elderly patients, HL doses were 1-4 mg/day while only 2 mg/day was used in the schizophrenics. At HL 2 mg/day dose in both age groups, mean plasma HL levels were approximately twice as high in the elderly patients compared to the schizophrenics(1.39 +/- 0.82 vs. 0.56 +/- 0.23 ng/ml, p < 0.02). RH plasma concentrations were almost 5 times greater in the elderly patients (0.54 +/- 0.35 vs. 0.09 +/- 0.05 ng/ml, p < 0.0001). These results suggest that HL plasma concentrations in the elderly are greater than in adult schizophrenic patients treated with similiar HL doses.

引用

页码：12 / 16

页数：5

共 24 条

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