FOXP1 promotes osteoblast differentiation via regulation of TGF-?/ALK-5 pathway

被引：3

作者：

Zhang, Min ^{[1
]}

Ma, Tao ^{[1
]}

Hu, Bin ^{[1
]}

Xiang, Weiwei ^{[2
]}

机构：

[1] Yijishan Hosp, Wannan Med Coll, Affiliated Hosp 1, Dept Hand & Foot, Wuhu 241000, Anhui, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Dept Orthoped, Ganzhou 341000, Jiangxi, Peoples R China

来源：

SCIENCEASIA | 2022年 / 48卷 / 04期

关键词：

FOXP1; osteoblast differentiation; TGF-; ALK-5; COLLAGEN-SYNTHESIS;

D O I：

10.2306/scienceasia1513-1874.2022.071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Osteoblast differentiation plays a crucial role in the development of skeleton. The purpose of this study was to investigate the role of FOXP1 in osteoblast differentiation. Expressions of FOXP1, ALP, OSX, and OCN were upregulated in MC3T3-E1 cells during osteoblast differentiation. Downregulation of FOXP1 inhibited the expressions of ALP, OSX, and OCN. ALP activity was reduced by inhibition of FOXP1. Osteoblast mineralization was suppressed by knockdown of FOXP1. The knockdown of FOXP1 also downregulated the expressions of TGF-??, ALK-5, and Smad4 and inhibited the phosphorylation of Smad2/3. Repression of ALK-5 attenuated the effects of FOXP1 on MC3T3-E1 cells during osteoblast differentiation. In summary, data of this study demonstrated that upregulation of FOXP1 enhanced osteoblast differentiation through enhancing activation of TGF-??/ALK-5 pathway.

引用

页码：423 / 428

页数：6

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