Lanthanide trifluoromethanesulfonate catalysed selective acylation of 10-deacetylbaccatin III

被引：50

作者：

Damen, EWP ^{[1
]}

Braamer, L ^{[1
]}

Scheeren, HW ^{[1
]}

机构：

[1] Univ Nijmegen, NSR Ctr Mol Struct Design & Synth, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 33期

关键词：

lanthanide; acylation; taxoids;

D O I：

10.1016/S0040-4039(98)01253-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective C-10 acylation of 10-deacetylbaccatin III to baccatin III and derivatives is very efficiently catalysed by lanthanide trifluoromethanesulfonates. Baccatin III, now readily available through this procedure, is an important precursor for an economically viable semisynthesis of paclitaxel and its derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6081 / 6082

页数：2

共 7 条

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