Solution X-ray Scattering Form Factors of Supramolecular Self-Assembled Structures

被引:53
作者
Szekely, Pablo [2 ]
Ginsburg, Avi [3 ]
Ben-Nun, Tal [3 ]
Raviv, Uri [1 ]
机构
[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Racah Inst Phys, IL-91904 Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Sch Comp Sci & Engn, IL-91904 Jerusalem, Israel
基金
以色列科学基金会;
关键词
PROTOFILAMENT NUMBER; INDUCED MICROTUBULES; NEUTRON-SCATTERING; PROTEIN; COMPLEXES; PHASE; RESOLUTION; MICROSCOPY; MEMBRANES; TUBULIN;
D O I
10.1021/la101433t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this paper, the analysis of several involved models, relevant for evaluating solution X-ray scattering form factors of supramolecular self-assembled structures, is presented. Different geometrical models are discussed, and the scattering form factors of several layers of those shapes are evaluated. The thickness and the electron density of each layer are parameters in those models. The models include Gaussian electron density profiles and/or uniform electron density profiles at each layer. Various forms of cuboid, layered, spherical, cylindrical, and helical structures are carefully treated. The orientation-averaged scattering intensities of those form factors are calculated. Similar classes of form factors are examined and compared, and their fit to scattering data of lipid bilayers, capsids of the Simian virus 40 virus-like particle and microtubule is discussed. A more detailed model of discrete helices composed of uniform spheres was derived and compared to solution X-ray scattering data of microtubules. Our analyses show that when high-resolution data are available the more detailed models with Gaussian electron density profiles or helical structures composed of spheres should be used to better capture all the elements in the scattering curves. The models presented in this paper may also be applied, with minor corrections, for the analysis of solution neutron scattering data.
引用
收藏
页码:13110 / 13129
页数:20
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