Synthesis and antimicrobial activity of tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives

被引：14

作者：

Kategaonkar, Amol H. ^{[1
]}

Labade, Vilas B. ^{[1
]}

Shinde, Pravin V. ^{[1
]}

Kategaonkar, Atul H. ^{[2
]}

Shingate, Bapurao B. ^{[1
]}

Shingare, Murlidhar S. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

[2] Maharashtra Inst Pharm, Pharmacol Lab, Pune 411038, Maharashtra, India

来源：

MONATSHEFTE FUR CHEMIE | 2010年 / 141卷 / 07期

关键词：

Tetrazolo[1,5-a]quinoline; Nitrile; Antibacterial; Antifungal; 7A-AZA-B-HOMO<7A; 7-D>TETRAZOLE ANALOGS; BIOLOGICAL-ACTIVITIES; FUSED PYRIDINES; NITRILES; ALDEHYDES; ANTIBACTERIAL; PROGESTERONE; TESTOSTERONE; INHIBITORS; CONVERSION;

D O I：

10.1007/s00706-010-0324-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives were synthesized for the first time via tetrazolo[1,5-a]quinoline derivatives. Elemental analysis, IR, (1)H NMR, (13)C NMR, and mass spectral data were used to elucidate the structures of all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi, Candida albicans and Aspergillus niger, in comparison with standard drugs. Some of the tested compounds showed significant antimicrobial activity.

引用

页码：787 / 791

页数：5

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