Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans

被引：123
作者：
Kim, DH
Ausubel, FM [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Biol Mol, Boston, MA 02114 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 01期
关键词：
D O I：
10.1016/j.coi.2004.11.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genetic and functional genomic approaches have begun to define the molecular determinants of pathogen resistance in Caenorhabditis elegans. Conserved signal transduction components are required for pathogen resistance, including a Toll/IL-1 receptor domain adaptor protein that functions upstream of a conserved p38 MAP kinase pathway. We suggest that this pathway is an ancestral innate immune signaling pathway present in the common ancestor of nematodes, arthropods and vertebrates, which is likely to predate the involvement of canonical Toll signaling pathways in innate immunity. We anticipate that the study of pathogen resistance in C. elegans will continue to provide evolutionary and mechanistic insights into the signal transduction and physiology of innate immunity.
引用
收藏
页码：4 / 10
页数：7
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