MicroRNA-203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin

被引：85

作者：

Bian, Ka ^{[1
,2
]}

Fan, Jing ^{[3
]}

Zhang, Xiang ^{[1
]}

Yang, Xin-Wei ^{[4
]}

Zhu, Hua-Yu ^{[1
]}

Wang, Lei ^{[1
]}

Sun, Jian-Yong ^{[1
]}

Meng, Yan-Ling ^{[5
]}

Cui, Peng-Cheng ^{[2
]}

Cheng, Shi-Yin ^{[2
]}

Zhang, Jian ^{[1
]}

Zhao, Jing ^{[1
]}

Yang, An-Gang ^{[1
,5
]}

Zhang, Rui ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Biochem & Mol Biol, State Key Lab Canc Biol, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Otolaryngol, Tangdu Hosp, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp, Dept Vasc & Endocrine Surg, Xian 710032, Peoples R China

[4] Fourth Mil Med Univ, Dept Pediat, Xijing Hosp, Xian 710032, Peoples R China

[5] Fourth Mil Med Univ, Dept Immunol, Xian 710032, Peoples R China

来源：

FEBS LETTERS | 2012年 / 586卷 / 06期

关键词：

MicroRNA; Cell cycle; Laryngeal carcinoma; Survivin; HEPATOCELLULAR-CARCINOMA; BLADDER-CANCER; EXPRESSION; GROWTH; GENE; PROLIFERATION; APOPTOSIS; PATHWAY; MODEL; HEAD;

D O I：

10.1016/j.febslet.2012.01.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have shown that miR-203 acts as a tumor-suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR-203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR-203. Moreover, silencing of survivin recapitulated the effect of miR-203 on cell cycle progression, whereas overexpression of survivin reversed this effect. Additionally, qRT-PCR showed the reciprocal relationship between miR-203 and survivin in laryngeal cancer tissues. These findings indicate that miR-203 inhibits the proliferation of laryngeal carcinoma cells by directly targeting survivin, suggesting its application in anti-cancer therapeutics. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：804 / 809

页数：6

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