Modulation of the tumor microenvironment by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma

被引：55

作者：

Yoshizaki, Tomokazu ^{[1
]}

Kondo, Satoru ^{[1
]}

Endo, Kazuhira ^{[1
]}

Nakanishi, Yosuke ^{[1
]}

Aga, Mitsuharu ^{[1
]}

Kobayashi, Eiji ^{[1
]}

Hirai, Nobuyuki ^{[1
]}

Sugimoto, Hisashi ^{[1
]}

Hatano, Miyako ^{[1
]}

Ueno, Takayoshi ^{[1
]}

Ishikawa, Kazuya ^{[1
]}

Wakisaka, Naohiro ^{[1
]}

机构：

[1] Kanazawa Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, Kanazawa, Ishikawa, Japan

来源：

CANCER SCIENCE | 2018年 / 109卷 / 02期

基金：

日本学术振兴会;

关键词：

cancer stem cell; Epstein-Barr virus; immune evasion; latent membrane protein 1; nasopharyngeal carcinoma; EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; LYMPH-NODE METASTASIS; LMP1; EXPRESSION; CELL-PROLIFERATION; DOWN-REGULATION; POOR-PROGNOSIS; T-CELLS; MEMBRANE-PROTEIN-1; INDUCTION;

D O I：

10.1111/cas.13473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Latent membrane protein 1 (LMP1) is a primary oncogene encoded by the Epstein-Barr virus, and various portions of LMP1 are detected in nasopharyngeal carcinoma (NPC) tumor cells. LMP1 has been extensively studied since the discovery of its transforming property in 1985. LMP1 promotes cancer cell growth during NPC development and facilitates the interaction of cancer cells with surrounding stromal cells for invasion, angiogenesis, and immune modulation. LMP1 is detected in 100% of pre-invasive NPC tumors and in approximately 50% of advanced NPC tumors. Moreover, a small population of LMP1-expressing cells in advanced NPC tumor tissue is proposed to orchestrate NPC tumor tissue maintenance and development through cancer stem cells and progenitor cells. Recent studies suggest that LMP1 activity shifts according to tumor development stage, but it still has a pivotal role during all stages of NPC development.

引用

页码：272 / 278

页数：7

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