Therapies from Fucoidan; Multifunctional Marine Polymers

被引：270
作者：
Fitton, Janet Helen [1 ]
机构：
[1] Marinova Pty Ltd, Cambridge, Tas 7170, Australia
来源：
MARINE DRUGS | 2011年 / 9卷 / 10期
关键词：
fucoidan; inflammation; fibrosis; viral infection; GALACTOSAMINE-INDUCED HEPATOPATHY; COMBINED PHASE-I; UNDARIA-PINNATIFIDA; SULFATED POLYSACCHARIDES; SNAKE-VENOM; LAMINARIA-JAPONICA; ANTIVIRAL ACTIVITY; FUCUS-VESICULOSUS; TOXICOLOGICAL EVALUATION; ANTICOAGULANT ACTIVITY;
D O I：
10.3390/md9101731
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.
引用
收藏
页码：1731 / 1760
页数：30
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