Anti-inflammatory Silent Agonists

被引：37

作者：

Horenstein, Nicole A. ^{[1
]}

Papke, Roger L. ^{[2
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2017年 / 8卷 / 10期

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTOR; NS6740;

D O I：

10.1021/acsmedchemlett.7b00368

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The traditional view of nicotinic acetylcholine receptors (nAChRs) is that they strictly exert their functions via their well-known ion channel activity. With the identification of the cholinergic anti-inflammatory pathway and the critical involvement of the alpha 7 nAChR, an alternate modality of function has emerged for the receptor involving metabotropic-like activity. The new emerging pharmacology for the receptor includes ligands termed silent agonists, which exert little or no ionotropic activity, yet are capable of modulating cellular inflammatory responses.

引用

页码：989 / 991

页数：3

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