Migraine and stroke: a complex association with clinical implications

被引:183
作者
Kurth, Tobias [4 ,5 ,6 ]
Chabriat, Hugues [1 ,2 ,3 ]
Bousser, Marie-Germaine [1 ,2 ,3 ]
机构
[1] Grp Hosp Lariboisiere Fernand Widal, Assistance Publ Hop Paris, Serv Neurol, Paris, France
[2] INSERM, U240, Paris, France
[3] Univ Paris Denis Diderot, Paris, France
[4] Univ Bordeaux, Inserm Unit Neuroepidemiol 708, Bordeaux, France
[5] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Boston, MA USA
基金
美国国家卫生研究院;
关键词
PATENT FORAMEN OVALE; CORTICAL SPREADING DEPRESSION; FAMILIAL HEMIPLEGIC MIGRAINE; CERVICAL ARTERY DISSECTION; CARDIOVASCULAR-DISEASE; ISCHEMIC-STROKE; RISK; WOMEN; AURA; HEADACHE;
D O I
10.1016/S1474-4422(11)70266-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Migraine and stroke are two common and heterogeneous neurovascular disorders with complex relations. Data show no firm association between stroke and migraine without aura by far the most common type of migraine but a doubling of the risk of ischaemic stroke in people who have migraine with aura. Migraine with aura is characterised by a low brain threshold for cortical spreading depression, the biological substrate of the aura, which can be triggered by many factors, including specific diseases that can by themselves increase the risk of ischaemic stroke. Whether the increased risk of ischaemic stroke applies to migraine with aura as a primary headache disorder or is partly due to migraine with aura secondary to other disorders remains to be elucidated.
引用
收藏
页码:92 / 100
页数:9
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