Stem cell therapy for cardiac dysfunction

被引：29
|
作者：
Matar, Amer A. [1 ]
Chong, James J. H. [1 ,2 ,3 ]
机构：
[1] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia
[2] Westmead Hosp, Dept Cardiol, Sydney, NSW, Australia
[3] Westmead Millennium Inst, Ctr Heart Res, Sydney, NSW, Australia
来源：
SPRINGERPLUS | 2014年 / 3卷
关键词：
Stem cells; Myocardial infarction; Cardiac regeneration; ACUTE MYOCARDIAL-INFARCTION; CARDIOSPHERE-DERIVED CELLS; LEFT-VENTRICULAR FUNCTION; BONE-MARROW-CELLS; ISCHEMIC CARDIOMYOPATHY; PROGENITOR CELLS; HEMATOPOIETIC STEM; TRANSENDOCARDIAL INJECTION; C-KIT(+) CELLS; HEART-FAILURE;
D O I：
10.1186/2193-1801-3-440
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Following significant injury, the heart undergoes induced compensation and gradually deteriorates towards impending heart failure. Current therapy slows but does not halt the resultant adverse remodeling. Stem cell therapy, however, has the potential to regenerate or repair infarcted heart tissue and therefore is a promising therapeutic strategy undergoing intensive investigation. Due to the wide range of stem cells investigated, it is difficult to navigate this field. This review aims to summarize the main types of stem cells (both of cardiac and extra-cardiac origin) that possess promising therapeutic potential. Particular focus is placed on clinical trials supporting this therapeutic strategy.
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收藏
页数：14
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