Plasma nitrate/nitrite (NOx) is not a useful biomarker to predict inherent cardiopulmonary bypass inflammatory response

被引:14
|
作者
Viaro, Fernanda [1 ]
Baldo, Caroline Floreoto [1 ]
Capellini, Verena Kise [1 ]
Celotto, Andrea Carla [1 ]
Bassetto, Solange [1 ]
Rodrigues, Alfredo Jose [1 ]
Barbosa Evora, Paulo Roberto [1 ]
机构
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Surg & Anat, Div Thorac & Cardiovascular Surg, Sao Paulo, Brazil
关键词
D O I
10.1111/j.1540-8191.2008.00649.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Aim: There were strong evidences that nitric oxide has capital importance in the progressive vasodilatation associated with varied circulatory shock forms, including systemic inflammatory response syndrome (SIRS), in patients undergoing cardiac surgeries for cardiopulmonary bypass (CPB). If CPB procedures, per se, are the inciting stimulus for inflammation, plasma nitrate/nitrite (NOx) excretion would be expected to be higher in these patients rather than in patients operated without CPB. In consequence, we hypothesized that increased levels of NOx would be predictive for vasoplegic syndrome. Methods: Thirty patients were assigned to three groups: Group 1-coronary artery bypass graft (CABG) roller pump CPB; Group 2-CABG centrifugal vortex pump CPB; and Group 3-heart valve surgery roller pump CPB. Sampling of venous blood for chemiluminescence plasma NOx dosage was achieved at the following time points: (1) before anesthesia induction; (2) after anesthesia induction; (3) before heparin infusion; (4) after heparin infusion; (5) CPB-30 minutes; (6) CPB-60 minutes; (7) before protamine infusion; (8) after protamine infusion; and (9) on return to the recovery area. Results: There were no intergroup differences regarding age and anesthetic regimen, and the number of arteries grafted was not different between the CABG groups. There were no NOx statistic differences, neither among the three groups of patients or among the surgery time. In addition, there was no correlation among NOx, lactate, and hemoglobin. Conclusions: Considering the inflammatory process intrinsic to CPB, this study reinforces the idea that plasma NOx is not useful as a biomarker of inflammatory response onset, which may or may not lead to SIRS and/or vasoplegic syndrome.
引用
收藏
页码:336 / 338
页数:3
相关论文
共 50 条
  • [31] Effects of corticosteroids on inflammatory response following cardiopulmonary bypass
    Anic, D
    Gasparovic, H
    Ivancan, V
    Batinic, D
    CROATIAN MEDICAL JOURNAL, 2004, 45 (02) : 158 - 161
  • [32] Cardiopulmonary Bypass-Induced Inflammatory Response: Pathophysiology and Treatment
    Bronicki, Ronald A.
    Hall, Mark
    PEDIATRIC CRITICAL CARE MEDICINE, 2016, 17 (08) : S272 - S278
  • [33] Cardiopulmonary bypass and the systemic inflammatory response: Effects on drug action
    Hall, RI
    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2002, 16 (01) : 83 - 98
  • [34] Inflammatory response to cardiopulmonary bypass with profound hypothermic circulatory arrest
    Loubser, PG
    Pundit, M
    Windsor, N
    Coselli, J
    ANESTHESIOLOGY, 1996, 85 (3A) : A149 - A149
  • [35] Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass
    Brasil, LA
    Gomes, WJ
    Salomao, R
    Buffolo, E
    ANNALS OF THORACIC SURGERY, 1998, 66 (01): : 56 - 59
  • [36] Inflammatory response after coronary revascularization with or without cardiopulmonary bypass
    Ascione, R
    Lloyd, CT
    Underwood, MJ
    Lotto, AA
    Pitsis, AA
    Angelini, GD
    ANNALS OF THORACIC SURGERY, 2000, 69 (04): : 1198 - 1204
  • [37] Inflammatory response to cardiopulmonary bypass using roller or centrifugal pumps
    Baufreton, C
    Intrator, L
    Jansen, PGM
    Velthuis, HT
    Le Besnerais, P
    Vonk, A
    Farcet, JP
    Wildevuur, CRH
    Loisance, DY
    ANNALS OF THORACIC SURGERY, 1999, 67 (04): : 972 - 977
  • [38] Strategies to attenuate maladaptive inflammatory response associated with cardiopulmonary bypass
    Banerjee, Debolina
    Feng, Jun
    Sellke, Frank W.
    FRONTIERS IN SURGERY, 2024, 11
  • [39] Inflammatory response associated with cardiopulmonary bypass and effect of methylprednisolone - Reply
    Chaney, MA
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2001, 122 (05): : 1052 - 1053
  • [40] Modulation of the inflammatory response to cardiopulmonary bypass by dopexamine and epidural anesthesia
    Bach, F
    Grundmann, U
    Bauer, M
    Buchinger, H
    Soltész, S
    Graeter, T
    Larsen, R
    Silomon, M
    ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2002, 46 (10) : 1227 - 1235