Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials

被引：53

作者：

McPherson, James C., III ^{[2
]}

Runner, Royce ^{[2
]}

Buxton, Thomas B. ^{[2
]}

Hartmann, John F. ^{[3
]}

Farcasiu, Dan

Bereczki, Ilona ^{[1
]}

Roth, Erzsebet ^{[1
]}

Tollas, Szilvia ^{[1
]}

Ostorhazi, Eszter ^{[4
]}

Rozgonyi, Ferenc ^{[4
]}

Herczegh, Pal ^{[1
]}

机构：

[1] Univ Debrecen, Dept Pharmaceut Chem, Med & Hlth Sci Ctr, H-4010 Debrecen, Hungary

[2] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA

[3] ElizaNor Biopharmaceut Inc, Princeton Jct, NJ USA

[4] Semmelweis Univ, Dept Dermatol Venerol & Dermatooncol, Microbiol Lab, H-1085 Budapest, Hungary

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 47卷

关键词：

Fluoroquinolone; Antibiotic; 1-Hydroxybisphosphonate; Osteotropic; Bone model; Adsorption; BONE RESORPTION; TISSUE CULTURE; BISPHOSPHONATES; PRODRUGS; OSTEOMYELITIS; DISSOLUTION; PREVENTION; DELIVERY; VITRO;

D O I：

10.1016/j.ejmech.2011.10.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1-Hydroxybisphosphonate derivatives of ciprofloxacin, gatifloxacin and moxifloxacin have been synthesized using Cu(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. The 1,2,3-triazol linked hydroxybisphosphonate derivative of ciprofloxacin exhibited antibacterial activity comparable to the parent antibiotic and all fluoroquinolone-bisphosphonates displayed osteotropic properties in a bone model. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：615 / 618

页数：4

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