Topiramate heterocyclic analogues: synthesis and spectroscopic characterization

被引：3

作者：

Martins Alho, Miriam A. ^{[1
]}

D'Accorso, Norma ^{[1
]}

机构：

[1] UBA, FCEN, Dept Quim Organ, Ctr Invest Hidratos Carbono,CIHIDECAR,CONICET, Intendente Guiraldes 2160,Ciudad Univ,C1428EGA, Buenos Aires, DF, Argentina

来源：

ARKIVOC | 2011年

关键词：

Topiramate; D-fructose; heterocyclic rings; spectroscopic data; DERIVATIVES; INHIBITORS; CURRENTS;

D O I：

10.3998/ark.5550190.0012.712

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we describe the synthesis of a set of heterocyclic analogues of topiramate as possible therapeutic agents for epileptic seizure treatment. The new compounds and their precursors were characterized by physical, as well as spectroscopic techniques. We verified that the preferential conformation in solution of the carbohydrate ring is twist-boat. The stereochemistry of the new asymmetric centre, generated during the heterocyclizations, was proposed using NOESY experiment. These novel compounds could help to elucidate the mechanism of action of the commercial drug used for this disease.

引用

页码：136 / 148

页数：13

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