Early Lymph Node Involvement by Mantle Cell Lymphoma Limited to the Germinal Center Report of a Case With a Novel "Follicular In Situ" Growth Pattern

被引:12
作者
Edlefsen, Kerstin L. [1 ]
Greisman, Harvey A. [1 ]
Yi, Hye Son [1 ]
Mantei, Kristin M. [2 ]
Fromm, Jonathan R. [1 ]
机构
[1] Univ Washington, Dept Lab Med, Seattle, WA 98109 USA
[2] CellNetix Pathol & Labs, Seattle, WA USA
关键词
Mantle cell lymphoma; In situ; Follicular; Pathogenesis; CHROMOSOMAL TRANSLOCATION; PROLIFERATION; DISEASE; PATIENT; GENES;
D O I
10.1309/AJCP6KFFGTC8PLVR
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Recently, several reports have described cases of "in situ" mantle cell lymphoma (MCL) in which scattered cyclin D1+ cells were present within the mantle zones of reactive-appearing lymphoid follicles. In this report, we describe an unusual histologic pattern of in situ MCL that was identified in a staging lymph node fir colonic adenocarcinoma resected 4 years before a diagnosis of symptomatic MCL. Retrospective immunohistochemical studies showed scattered cyclin D1-expressing cells within otherwise reactive germinal centers but not in the surrounding mantle zones. The presence of early MCL cells limited to reactive germinal centers represents a novel "follicular in situ" growth pattern for MCL, which overlaps morphologically with reactive follicular hyperplasia and follicular lymphoma and which could have implications for MCL pathogenesis.
引用
收藏
页码:276 / 281
页数:6
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