The Brain Basis of Comorbidity in Neurodevelopmental Disorders

被引:6
作者
Licari, Melissa K. [1 ]
Finlay-Jones, Amy [1 ]
Reynolds, Jess E. [2 ]
Alvares, Gail A. [1 ]
Spittle, Alicia J. [3 ,4 ,5 ]
Downs, Jenny [1 ]
Whitehouse, Andrew J. O. [1 ]
Leonard, Helen [1 ]
Evans, Kiah L. [1 ,6 ]
Varcin, Kandice [1 ]
机构
[1] Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia
[2] Univ Calgary, Dept Radiol, Calgary, AB, Canada
[3] Murdoch Childrens Res Inst, Parkville, Vic, Australia
[4] Royal Womens Hosp, Parkville, Vic, Australia
[5] Univ Melbourne, Dept Physiotherapy, Parkville, Vic, Australia
[6] Curtin Univ, Sch Occupat Therapy Social Work & Speech Pathol, Perth, WA, Australia
关键词
Neurodevelopmental disorders; Comorbidity; Autism spectrum disorder; Attention deficit hyperactivity disorder; Developmental coordination disorder; Neuroimaging; DEVELOPMENTAL COORDINATION DISORDER; AUTISM SPECTRUM DISORDERS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; PRENATAL ALCOHOL EXPOSURE; DOMAIN CRITERIA RDOC; WHITE-MATTER; 16P11.2; DELETION; DSM-IV; CHILDREN; ADHD;
D O I
10.1007/s40474-019-0156-7
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Purpose of ReviewResearch examining brain development in neurodevelopmental disorders has largely comprised small-scale studies on individual disorders. Findings have confirmed neurodevelopmental disruption and deviation; however, comorbidity between disorders continues to challenge our understanding of brain-behaviour associations. This review discusses early brain development and the etiological factors that may give rise to atypical developmental trajectories, along with neuroimaging insights into neurodevelopmental disorders.Recent FindingsEvidence related to the behavioural, neurological, genetic and environmental factors impacting on brain development is examined. Large neuroimaging databases are currently being used to identify early alterations in brain development and areas of divergence and convergence between disorders are reviewed.SummaryInvestigative approaches based on diagnostic groups continue to challenge our ability to elucidate regions of the brain linked to behavioural phenotypes, especially those known to be shared across disorders.
引用
收藏
页码:9 / 18
页数:10
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